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Mesenchymal Stem Cells and Reticulated Platelets: New Horizons in Multiple Myeloma.
Hematol Rep
November 2024
Grupo Inmunobiología y Biología Celular, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá 110111, Colombia.
Multiple myeloma (MM) is a malignant plasma cell disorder characterized by the accumulation of abnormal plasma cells in the bone marrow. Mesenchymal stem cells (MSCs) and reticulated platelets (RPs) have been implicated in the pathogenesis of MM. This narrative review aims to explore the role of MSCs and RPs in the pathophysiology of MM, particularly their clinical use as possible variables of prognostic value in this hematologic neoplasia.
View Article and Find Full Text PDFPlatelet Function, Platelet Size and Content of Reticulated Platelets: Interactions in Patients Receiving Dual Antiplatelet Therapy.
Cells
October 2024
Chazov National Medical Research Center of Cardiology, Russian Ministry of Health, 15a, Academician Chazov Str., Moscow 121552, Russia.
Increased platelet activity is a risk factor of thrombotic events in cardiovascular patients. We studied the relationship between platelet function, platelet size, and the content of reticulated platelets (RP) in patients with coronary heart disease (CHD, n = 55) and acute coronary syndrome (ACS, n = 95) receiving acetylsalicylic acid + clopidogrel or ticagrelor, respectively. The control group consisted of patients with risk factors for CHD, but with no CHD/ACS and free of antiplatelet drugs (n = 66).
View Article and Find Full Text PDFPatients with Waldenström macroglobulinemia have impaired platelet and coagulation function.
Blood Adv
November 2024
Division of Genome Science and Cancer, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.
Article Synopsis
- Patients with Waldenström macroglobulinemia (WM) experience symptoms like cytopenias, fatigue, and bleeding, often exacerbated by therapeutics like Bruton's tyrosine kinase inhibitors (BTKis).
- A study analyzed hemostatic dysfunction in WM patients, comparing samples from untreated patients, those on BTKis, and healthy donors, using various blood tests to assess platelet function and clotting potential.
- Results showed that WM patients had decreased platelet reticulation, slower thrombin generation, and impaired hemostatic function due to high levels of IgM, indicating serious disturbances in blood coagulation despite receiving treatment.
Immature Platelet Fraction and Acute Coronary Syndrome; a Systematic Review and Meta-Analysis.
Arch Acad Emerg Med
April 2024
Cardiovascular Research Center, Alborz University of Medical Sciences, Alborz, Iran.
Article Synopsis
- Immature Platelet Fraction (IPF) measures the number of reticulated platelets in blood and may serve as a valuable biomarker in diagnosing and assessing patients with Acute Coronary Syndrome (ACS).
- A systematic review of 15 studies including 2,030 ACS patients showed significant differences in IPF levels compared to healthy individuals and stable angina patients, indicating its potential diagnostic utility.
- The findings suggest that higher IPF levels may occur in specific ACS subtypes, particularly during the acute phase of myocardial infarction, making it a promising tool for early diagnosis and differentiation of ACS.
Author's reply: "Reticulated platelets in cirrhosis - just a surrogate for thrombocytopenia?".
Dig Liver Dis
September 2024
Department of Medicine, University of Padova, Padova, Italy; First Chair of Internal Medicine and Thrombotic and Haemorrhagic Disease Unit, Padova University Hospital, Padova, Italy.
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