Histamine inactivation in the brain: aspects of N-methylation.

This report deals with molecular and anatomical site of histamine N-methylation assumed to be the exclusive route of HA inactivation. The methyl transfer from the -S-CH3 of S-adenosyl-L-methionine to the ring (tele)-nitrogen of histamine, appears as much more complex than a one-step transformation. It seems that -S-CH3 is transformed before being transferred to the nitrogen of the acceptor probably via methanol (formaldehyde) formation. For localizations of transmethylation of neuronal histamine we assume at least a two-compartment model in which glia participate to a significant extent. The uptake of neuronal HA into glial cells might be the first step of histamine inactivation.