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Quantitative DNA metabarcoding reveals species composition of a macrocyclic lactone and pyrantel resistant cyathostomin population in the UK.
Int J Parasitol Drugs Drug Resist
December 2024
Bristol Veterinary School, University of Bristol, Bristol, BS40 5DU, UK.
Cyathostomins are the most abundant equid endoparasites globally. There are approximately fifty cyathostomin species and, whilst they occupy distinct niches within the large intestine, they are generally considered to share similar characteristics in terms of pathogenicity and response to drug treatment. There are three classes of anthelmintic licensed in the UK to treat cyathostomins (benzimidazoles, tetrahydropyrimidines and macrocyclic lactones) and cases of resistance have been documented for all classes.
View Article and Find Full Text PDFFerulic acid alleviates long-term avermectin-induced damage to the spleen of carp and restores its inflammatory response and oxidative balance.
J Environ Sci (China)
May 2025
Jiangsu Key Laboratory of Marine Bioresources and Environment, Co-Innovation Center of Jiangsu Marine Bio-industry Technology, Jiangsu Marine Pharmaceutical Resources Development Engineering Research Center, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, College of Pharmacy, Jiangsu Ocean University, Lianyungang 222005, China. Electronic address:
Extensive use of avermectin (AVM) in agriculture can seriously contaminate fish in aquaculture. Ferulic acid (FA) is a strong antioxidant sourced from plants and is widely applied in food and medicine, but its protective function on the immunological damage caused by AVM is still lacking. In this study, carp were chronically exposed to (1/10 96 hr LC) AVM for 30 day(s), with a dietary supplement of FA (400 mg/kg) to assess its effects on carp spleen.
View Article and Find Full Text PDFEscalating Threat of Drug-Resistant Human Scabies: Current Insights and Future Directions.
J Clin Med
September 2024
Department of Dermatology, St Pierre-Brugmann-HUDERF University Hospitals, Université Libre de Bruxelles, 1000 Brussels, Belgium.
Article Synopsis
- Scabies is a common skin condition that poses serious public health challenges, especially with the rise of drug-resistant cases complicating treatment efforts.
- A literature review analyzing studies from 2000 to August 2024 revealed significant resistance to the common treatment permethrin, mainly due to genetic changes in the mites.
- There is a pressing need for new management strategies and updated treatment guidelines, along with better infection control and research into alternative therapies to combat this growing threat.
Circulation of COVID-19-Related Medicines on Japanese Websites during the COVID-19 Pandemic and Their Quality and Authenticity.
Am J Trop Med Hyg
November 2024
Medi-Quality Security Institute, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
Substandard and falsified medical products for treating COVID-19 have spread worldwide. These medicines have entered Japan through personal importation of products purchased via the Internet. In this study, we investigated the circulation of 19 COVID-19-related medicines on the Internet in Japan and evaluated the pharmaceutical quality and authenticity of 2 medicines (dexamethasone tablets and ivermectin tablets) obtained online.
View Article and Find Full Text PDFSurvival and growth of M. perstans larvae in a human colon carcinoma cell line-based in vitro culture.
Exp Parasitol
October 2024
Institute of Medical Microbiology, Immunology and Parasitology (IMMIP), University Hospital Bonn (UKB), Bonn, Germany; German-West African Centre for Global Health and Pandemic Prevention (G-WAC), Partner Site Bonn, Bonn, Germany. Electronic address:
Mansonella perstans infections are widespread in Sub-Saharan Africa and Central and South America and thus can be considered as the most prevalent parasite of man in tropical Africa. In contrast to the high prevalence, knowledge about the biology of this filarial nematode is restricted and no effective treatment regimens of this ivermectin-resistant parasite is lacking. An obstacle for the research is that M.
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