A Pt(II)-Dip complex stabilizes parallel c-myc G-quadruplex.

Chem Commun (Camb)

Division of Chemistry and Biological Chemistry, Nanyang Technological University, 21 Nanyang Link, 637371, Singapore.

Published: May 2013

A new G-quadruplex (GQ) stabilizer, [Pt(Dip)2](PF6)2 (Dip: 4,7-diphenyl-1,10-phenanthroline), is prepared by the microwave irradiation method. The complex can highly stabilize G-quadruplex, but has negligible interactions with duplex DNA. Aromatic anchors on the polypyridyl ligands bestow the stabilizer with a high binding preference towards parallel GQ.

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Source
http://dx.doi.org/10.1039/c3cc40868jDOI Listing

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