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How does an intervention work?-English Version : Development of an effect model for a complex intervention to prevent recurring or persistent pain using the example of PAIN 2.0.
Schmerz
January 2025
University Pain Center, University Hospital Carl Gustav Carus, Dresden, Germany.
In addition to the usual evaluation approach (usually a clinical randomized trial in the sense of the question: does an intervention work), complex interventions require further systematic investigations to prove their effectiveness. The role of the context in which the intervention is delivered is essential here, as is consideration of the question of why an intervention works (or does not work). Detailed recommendations exist for the planning and implementation of effectiveness studies on complex interventions, to which interdisciplinary multimodal pain therapy undoubtedly belongs.
View Article and Find Full Text PDF[How does an intervention work?-German Version. : Development of an effect model for a complex intervention to prevent recurring or persistent pain using the example of PAIN 2.0].
Schmerz
January 2025
UniversitätsSchmerzCentrum, Klinik für Anästhesiologie, Universitätsklinikum Carl Gustav Carus Dresden, Dresden, Deutschland.
In addition to the usual evaluation approach (usually a clinical randomized trial in the sense of the question: does an intervention work), complex interventions require further systematic investigations to prove their effectiveness. The role of the context in which the intervention is delivered is essential here, as is consideration of the question of why an intervention works (or does not work). Detailed recommendations exist for the planning and implementation of effectiveness studies on complex interventions, to which interdisciplinary multimodal pain therapy undoubtedly belongs.
View Article and Find Full Text PDFHow norms-shifting interventions foster community-level social and behavior change: new insights from a synthesis of realist evaluations of community-level interventions.
Glob Health Promot
January 2025
Formerly with Georgetown University, Medical Center Research Development Unit, Washington, DC, USA.
Social norms, the informal rules that influence behavior, play essential roles in shaping people's behavior. Community-based norms-shifting interventions (NSIs) identify gender and other social norms linked to unhealthy behaviors and implement activities to promote collective change by encouraging communities to reflect on and question these norms. Though NSIs are gaining international traction in social and behavior change programming for health promotion, how change occurs needs to be clearly understood in African and other contexts.
View Article and Find Full Text PDFCellular signalling protrusions enable dynamic distant contacts in spinal cord neurogenesis.
Biol Open
January 2025
Faculty of Biology Medicine and Health, The University of Manchester, Manchester M13 9PT, UK.
In the developing mouse ventral spinal cord, HES5, a transcription factor downstream of Notch signalling, is expressed as evenly spaced clusters of high HES5-expressing neural progenitor cells along the dorsoventral axis. While Notch signalling requires direct membrane contact for its activation, we have previously shown mathematically that contact needs to extend beyond neighbouring cells for the HES5 pattern to emerge. However, the presence of cellular structures that could enable such long-distance signalling was unclear.
View Article and Find Full Text PDFEarly Identification of Low Scorers: The Role of Formative Assessments and Summative Assessments.
Cureus
December 2024
Physiology, Raiganj Government Medical College and Hospital, Raiganj, IND.
Background Identifying students who are low scorers is essential for providing timely interventions and support. Traditional methods of identifying such students often rely on summative assessments, such as end-of-term exams. However, formative assessments offer valuable insights into students' understanding, strengths, and weaknesses.
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