Diamond-lipid hybrids enhance chemotherapeutic tolerance and mediate tumor regression.

Adv Mater

Department of Biomedical Engineering Northwestern University Evanston, Illinois, 60208, USA ;Mechanical Engineering Northwestern University Evanston, Illinois, 60208, USA; Institute for Bionanotechnology in Medicine (IBNAM) Robert H. Lurie Comprehensive Cancer Center Northwestern University Chicago. Illinois, 60611, USA.

Published: July 2013

Self-assembled nanodiamond-lipid hybrid particles (NDLPs) harness the potent interaction between the nanodiamond (ND)-surface and small molecules, while providing a mechanism for cell-targeted imaging and therapy of triple negative breast cancers. Epidermal growth factor receptor-targeted NDLPs are highly biocompatible particles that provide cell-specific imaging, promote tumor retention of ND-complexes, prevent epirubicin toxicities and mediate regression of triple negative breast cancers.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3872062PMC
http://dx.doi.org/10.1002/adma.201300343DOI Listing

Publication Analysis

Top Keywords

triple negative
8
negative breast
8
breast cancers
8
diamond-lipid hybrids
4
hybrids enhance
4
enhance chemotherapeutic
4
chemotherapeutic tolerance
4
tolerance mediate
4
mediate tumor
4
tumor regression
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!