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10-million-years AGO: argonaute on chromatin in yeast and human, a conserved mode of action? | LitMetric
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10-million-years AGO: argonaute on chromatin in yeast and human, a conserved mode of action?

Annick Harel-Bellan Maya Ameyar Zazoua Christophe Rachez Christian Muchardt Eric Batsché

Transcription

Université Paris Sud; Laboratoire Epigenetique et Cancer; Formation de Recherche en Evolution 3377; Gif-Sur-Yvette, France; Centre National de la Recherche Scientifique (CNRS); Gif-Sur-Yvette, France; Commissariat à l'Energie Atomique (CEA); Saclay; Gif-sur-Yvette, France.

Published: March 2015

Whereas in yeast the function and mode of action of nuclear RNAi are well documented, mammalian nuclear RNAi is a matter of debates. Several papers support a role for nuclear Argonaute in alternative splicing. However, the molecular mechanism remains elusive. Here, we discuss the human nuclear RNAi mechanism in light of what is known of the yeast process.

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 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042589PMC
http://dx.doi.org/10.4161/trns.24582DOI Listing

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