Stress ulcers are a common complication in critically ill patients, but the underlying mechanism is little known. This study characterized the function of the p50 subunit of NF-κB in an experimental model of cold immobilization stress-induced gastric ulcers. Stress-induced gastric mucosal inflammation and gastric injury were examined in wild-type and NF-κB p50-deficient mice. When subjected to cold immobilization stress, NF-κB was rapidly activated in the gastric mucosa in WT mice whereas the majority of κB DNA-binding activity was abrogated from p50(-/-) mice. Deficiency of p50 ameliorated stress-induced expression of TNF-α, MIP-2, and ICAM-1, resulting in reduced mucosal accumulation of neutrophils and gastric injury. These data indicated a critical role for the p50 in the gastric mucosal inflammatory response to cold restraint stress.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2013.03.112DOI Listing

Publication Analysis

Top Keywords

cold immobilization
12
stress-induced gastric
12
immobilization stress-induced
8
gastric ulcers
8
gastric mucosal
8
gastric injury
8
gastric
7
absence nf-κb
4
nf-κb subunit
4
p50
4

Similar Publications

Recovery methods, such as thermal interventions, have been developed to promote optimal recovery and maximize long-term training adaptations. However, the beneficial effects of these recovery strategies remain a source of controversy. This narrative review aims to provide a detailed understanding of how cold and heat interventions impact long-term training adaptations.

View Article and Find Full Text PDF

Nano fish bone prepared by high-energy media milling extends the shelf life of tofu during cold storage: Unlocking the restriction on water mobility.

Food Chem

February 2025

College of Food Science and Technology/National R&D Branch Center for Conventional Freshwater Fish Processing (Wuhan), Huazhong Agricultural University, Wuhan 430070, China; National R & D Branch Center for Conventional Freshwater Fish Processing, Wuhan, Hubei Province 430070, China. Electronic address:

Nano fish bone (NFB) was produced by high-energy media milling. The NFB was composed of circular crystals (approximately 110 nm) and fibrous collagen/peptide. Effects of NFB on the quality and microorganisms of glucono-d-lactone (GDL)-induced tofu stored at 4 °C were investigated.

View Article and Find Full Text PDF

Searching for variables representing the response to cold stress in mediterranean Geotrupinae reveals an association between heat and cold tolerances.

J Therm Biol

December 2024

Department of Biogeography and Global Change, Museo Nacional de Ciencias Naturales-CSIC, Madrid, Spain. Electronic address:

The study of cold tolerance is imperative for understanding insect activity across spatial and temporal gradients. Here, we assessed various physiological variables to discern the response to cold stress in Mediterranean earth-boring dung beetles, utilizing an infrared thermography protocol initially developed for detecting heat stress variables. Subsequently, we conducted a joint analysis of heat and cold stress variables to explore the extent of congruence between their responses.

View Article and Find Full Text PDF

Thermal Treatment Induced Crystal Development and Crystal Orientation Change in Electrospun Coaxial Fibers Comprising Dual Crystalline Polymers.

Macromol Rapid Commun

November 2024

Department of Chemical Engineering, National Cheng Kung University, No. 1, University Road, Tainan City, 701, Taiwan.

This study investigates the crystallization behavior of electrospun coaxial fibers composed of crystalline poly(ethylene oxide) (PEO) in the core and crystalline poly(L-lactide) (PLLA) in the sheath. The influence of cold crystallization temperature and premelting temperature on the crystallization of PEO and PLLA is investigated. At a cold crystallization temperature of ≤60 °C, PLLA remained immobile.

View Article and Find Full Text PDF

The enzyme catechol 1,2-dioxygenase (CAT) plays a critical role in the biosynthesis pathway of cis, cis-muconic acid (CCMA), which serves as an indispensable raw material for various industrial applications. In this research, we cloned a novel cold-adapted CAT (HaCAT) from the Antarctic sea ice bacterium Halomonas sp. ANT108.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!