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Haemodialysis-associated thrombocytopenia: interactions among the immune system, membranes and sterilisation methods.
BMJ Case Rep
September 2019
Section of Hematology Oncology & Women's Health Unit, Boston University School of Medicine, Boston, Massachusetts, USA.
We present a case of a 47-year-old man with severe thrombocytopenia. The differential diagnosis for thrombocytopenia is wide. The assessment includes an evaluation for falsely low platelet counts (pseudothrombocytopenia), immune-mediated platelet destruction, bone marrow dysfunction, or increased consumption and sequestration.
View Article and Find Full Text PDFThrombocytopenia in the setting of hemodialysis using biocompatible membranes.
Case Rep Med
October 2012
School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Thrombocytopenia is a known potential side effect of hemodialysis, however, it is rarely seen in patients who undergo hemodialysis using biocompatible membranes. This case demonstrates hemodialysis-associated thrombocytopenia with use of biocompatible dialysis membranes that expose blood directly to polysulfone. The thrombocytopenia resolved in this patient when the dialysis membrane was changed to a biocompatible model with a polyethylene glycol barrier layer preventing direct interaction between patient blood and polysulfone.
View Article and Find Full Text PDFHemodialysis effect on platelet count and function and hemodialysis-associated thrombocytopenia.
Kidney Int
July 2012
Department of Medicine, University of Illinois at Chicago School of Medicine, Chicago, IL 60612, USA.
Substantial activation of platelets can occur in the course of hemodialysis. Platelet surface markers show evidence of platelet degranulation. Some activation occurs due to exposure of blood to the roller pump segment and microbubbles may play a role.
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