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Characterization of a multiresistance optrA- and lsa(E)-harbouring unconventional circularizable structure in Streptococcus suis.
J Antimicrob Chemother
October 2024
National Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Objectives: To identify novel genetic elements facilitating the horizontal transfer of the oxazolidinone/phenicol resistance gene optrA and the pleuromutilin-lincosamide-streptogramin A resistance gene lsa(E) in Streptococcus suis.
Methods: The complete genomes of S. suis HB18 and two transconjugants were obtained using both the Illumina and Nanopore platforms.
Tandem amplification of a plasmid-borne tet(A) variant gene confers tigecycline resistance in Escherichia coli.
J Antimicrob Chemother
June 2024
College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, P. R. China.
Objectives: To elucidate the mechanism of tigecycline resistance in Escherichia coli that is mediated by the tet(A) variant gene.
Methods: E. coli strain 573 carried a plasmid-borne tet(A) variant gene, tentatively designated tet(A)TIG, that conferred decreased tigecycline susceptibility (MIC 0.
Characterization of an optrA-harbouring unconventional circularizable structure located on a novel ICESa2603 family-like integrative and conjugative element ICESsuHN38 in Streptococcus suis.
J Antimicrob Chemother
August 2023
State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China.
Objectives: To identify the novel genetic elements involved in the horizontal transfer of the oxazolidinone/phenicol resistance gene optrA in Streptococcus suis.
Methods: Whole-genome DNA of the optrA-positive isolate S. suis HN38 was subjected to WGS via both Illumina HiSeq and Oxford Nanopore platforms.
Excision and integration of unconventional circularizable structures involving the erm(B) gene in enterococci.
Vet Microbiol
October 2022
College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, PR China. Electronic address:
Traditionally, insertion sequences (ISs) play a major role in disseminating antimicrobial resistance genes (ARGs) in bacteria through transposition and translocation, forming regions that contain multiple ARGs flanked by single or multiple copies of IS. In addition, unconventional circularizable structures (UCSs), lacking recombinase genes but being surrounded by directly repeated sequences (DRs) of various sizes which do not contain transposase genes, were reported to be involved in the dissemination of ARGs. In this study, a novel UCS was identified on plasmid pE508-2 in E.
View Article and Find Full Text PDFStudies on the Transmission of a Tigecycline Resistance-Mediating (A) Gene Variant from Enterobacter hormaechei via a Two-Step Recombination Process.
Microbiol Spectr
June 2022
College of Veterinary Medicine, Henan Agricultural Universitygrid.108266.b, Zhengzhou, People's Republic of China.
To investigate the contribution of a (A) variant to tigecycline resistance in Enterobacter hormaechei and the recombination events that occurred during transmission of this variant. MICs were determined by broth microdilution. G17 was characterized by PCR, transfer assay, S1-PFGE, Southern blot hybridization, and WGS analysis.
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