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Surface receptor-targeted Protein-based nanocarriers for drug delivery: Advances in cancer therapy.
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Department of Biotechnology, Kalasalingam Academy of Research and Education (Deemed to be University), Anand Nagar, School of Bio, Chemical & Process Enginneering, Krishnankoil, Krishnan Kovil, Tamil Nadu, 626126, INDIA.
Significant progress has been made in cancer therapy with protein-based nanocarriers targeted directly to surface receptors for drug delivery. The nanocarriers are a potentially effective solution for the potential drawbacks of traditional chemotherapy, such as lack of specificity, side effects, and development resistance. Peptides as nanocarriers have been designed based on their biocompatible, biodegradable, and versatile functions to deliver therapeutic agents into cancer cells, reduce systemic toxicity, and maximize therapy efficacy through utilizing targeted ligands such as antibodies, amino acids, vitamins, and other small molecules onto protein-based nanocarriers and thus ensuring that drugs selectively accumulate in the cancer cells instead of healthy organs/drug release at a target site without effects on normal cells, which inherently caused less systemic toxicity/off-target effect.
View Article and Find Full Text PDFTransforming healthcare: Saudi Arabia's vision 2030 healthcare model.
J Pharm Policy Pract
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School of Medical and Life Sciences, Sunway University, Sunway City, Malaysia.
Vision 2030 represents Saudi Arabia's strategic socio-economic plan aimed at promoting economic diversification and enhancing living standards. Launched in April 2016, this vision describes an innovative healthcare plan to improve services and outcomes. The merits and drawbacks of public hospitals' 'Model of Care' are examined in this study.
View Article and Find Full Text PDFTreatment of Femoral Neck Fractures in Adults With Improved Biplane Double-Supported Screw Fixation and Femoral Neck System: Complications and Surgical Techniques.
Orthop Surg
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Division of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Objectives: Treating femoral neck fractures remains a significant challenge for orthopedic surgeons and imposes a substantial economic burden on developing regions. Current novel internal fixation methods demonstrate excellent biomechanical performance. However, these new internal fixation methods are still associated with various complications.
View Article and Find Full Text PDFMulti-pathway oxidative stress amplification via controllably targeted nanomaterials for photoimmunotherapy of tumors.
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Yantai Engineering Research Center for Digital Technology of Stomatology, School of Stomatology, Binzhou Medical University, Yantai, 264003, China.
Photoimmunotherapy, which combines phototherapy with immunotherapy, exhibits significantly improved therapeutic effects compared with mono-treatment regimens. However, its use is associated with drawbacks, such as insufficient reactive oxygen species (ROS) production and uneven photosensitizer distribution. To address these issues, we developed a controllable, targeted nanosystem that enhances oxidative stress through multiple pathways, achieving synergistic photothermal, photodynamic, and immunotherapy effects for tumor treatment.
View Article and Find Full Text PDFRational Design of Quinoidal Conjugated Polymers for Photothermal Antibacterial Therapy.
Macromol Rapid Commun
January 2025
School of Materials Science and Engineering, Hebei University of Technology, Tianjin, 300401, P. R. China.
The increasing prevalence of antibiotic resistance, driven by the overuse and misuse of conventional antibiotics, has become a critical public health concern. Photothermal antibacterial therapy (PTAT) utilizes heat generated by photothermal agents under light exposure to inhibit bacterial growth without inducing resistance, attracting more and more attention. Quinoid conjugated polymers, especially para-azaquinodimethane (AQM) polymer, are a class of organic semiconductors known for efficient π-electron delocalization, near-infrared absorption, and narrow bandgap, showing great potential in the application of photothermal reagents.
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