AI Article Synopsis
- - Anandamide, part of the endocannabinoid system, shows decreases in animals after repeated THC use, but its effects in humans had not been studied before.
- - In a study with 33 volunteers, including 20 cannabis users, frequent users exhibited lower cerebrospinal fluid (CSF) levels of anandamide and higher serum levels of 2-arachidonoylglycerol (2-AG).
- - There was a negative correlation between CSF anandamide levels and persistent psychotic symptoms in drug-free individuals, indicating higher anandamide levels may reduce the risk of such symptoms after cannabis use.
Article Abstract
Anandamide is a ligand of the endocannabinoid system. Animals show a depletion following repeated Δ(9)-tetrahydrocannabinol (THC) administration but the effect of cannabis use on central nervous system levels of endocannabinoids has not been previously examined in humans. Cerebrospinal fluid (CSF) levels of the endocannabinoids anandamide, 2-arachidonoylglycerol (2-AG) and related lipids were tested in 33 volunteers (20 cannabis users). Lower levels of CSF anandamide and higher levels of 2-AG in serum were observed in frequent compared with infrequent cannabis users. Levels of CSF anandamide were negatively correlated with persisting psychotic symptoms when drug-free. Higher levels of anandamide are associated with a lower risk of psychotic symptoms following cannabis use.
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| http://dx.doi.org/10.1192/bjp.bp.112.121178 | DOI Listing |
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