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Enhanced Analytical Performance in CYFRA 21-1 Detection Using Lateral Flow Assay with Magnetic Bioconjugates: Integration and Comparison of Magnetic and Optical Registration.
Biosensors (Basel)
December 2024
Prokhorov General Physics Institute of the Russian Academy of Sciences, 38 Vavilov Street, 119991 Moscow, Russia.
A novel approach to developing lateral flow assays (LFAs) for the detection of CYFRA 21-1 (cytokeratin 19 fragment, a molecular biomarker for epithelial-origin cancers) is proposed. Magnetic bioconjugates (MBCs) were employed in combination with advanced optical and magnetic tools to optimize assay conditions. The approach integrates such techniques as label-free spectral-phase interferometry, colorimetric detection, and ultrasensitive magnetometry using the magnetic particle quantification (MPQ) technique.
View Article and Find Full Text PDFDNA Mimic Foldamer Recognition of a Chromosomal Protein.
Angew Chem Int Ed Engl
December 2024
Ludwig-Maximilians-Universitat Munchen, Pharmacy, Butenandtstraße 5 - 13, 81377, Munich, GERMANY.
Helical aromatic oligoamide foldamers bearing anionic side chains that mimic the overall shape and charge surface distribution of DNA were synthesized. Their interactions with chromosomal protein Sac7d, a non-sequence-selective DNA-binder that kinks DNA, were investigated by Surface Plasmon Resonance (SPR), Isothermal Titration Calorimetry (ITC), Circular Dichroism spectroscopy (CD), melting curve analysis, Atomic Force Microscopy (AFM), and Nuclear Magnetic Resonance (NMR), as well as by single crystal X-ray crystallography. The foldamers were shown to bind to Sac7d better than a DNA duplex of comparable length.
View Article and Find Full Text PDFAir versus supplemental oxygen for resuscitation of term or late preterm infants at birth.
Cochrane Database Syst Rev
December 2024
Division of Neonatology, Dr. von Hauner'sches Children's Hospital, Ludwig-Maximilians-Universität Munich, Munich, Germany.
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: Primary objective To assess the benefits and harms of air compared with supplemental oxygen for resuscitation of term or late preterm infants at birth in reducing rates of mortality and long-term neurodevelopmental impairment (NDI). Secondary objectives To assess whether the benefits and harms of air compared with supplemental oxygen differ according to different oxygen concentrations, gestational age (GA), whether oxygen was titrated to saturation curves and the income of the study country.
View Article and Find Full Text PDFCurcumin-Derived (3-Aminopropyl)trimethoxysilane-Functionalized Carbon Quantum Dots: A Fluorometric and Colorimetric Nanoprobe for Picric Acid Detection, Antioxidant Activity, and Liposome Encapsulation.
ACS Appl Mater Interfaces
December 2024
Department of Chemistry, Indian Institute of Technology (BHU), Varanasi 221005, Uttar Pradesh, India.
Creating an analytical probe to track extremely mutagenic picric acid (PA) is essential for human health and the environment. Here, we developed a straightforward and quick fluorescence analytical method utilizing 3-aminopropyltrimethoxysilane (3-APTMS)-functionalized curcumin carbon quantum dots (CQDs) for the fast and selective detection of PA. Solvothermal carbonization and functionalization of curcumin with 3-APTMS were used to create multifunctional CQDs, which were then characterized using UV-vis spectroscopy, Fourier transform infrared (FTIR), X-ray diffraction (XRD), ζ-potential, transmission electron microscopy (TEM), and X-ray photoelectron spectroscopy (XPS).
View Article and Find Full Text PDFLabel-free determination of glypican-3 using PtPd@H-rGO nanocomposites decorated light-addressable potentiometric sensor.
Bioelectrochemistry
April 2025
School of Life and Environmental Sciences, Guilin University of Electronic Technology, Guilin, Guangxi 541004, PR China. Electronic address:
Glypican-3 (GPC3) is exclusively overexpressed in most Hepatocellular carcinoma (HCC) tissue but not in normal liver tissue, making it a promising biomarker for the precise detection of HCC. In this paper, a label-free light-addressable potentiometric sensor (LAPS) decorated by platinumpalladium-hemin-reduced graphene oxide nanocomposites (PtPd@H-rGO NCs) was constructed for determination of GPC3. The GPC3 aptamer (GPC3) and PtPd@H-rGO NCs were modified on the surface of silicon-based LAPS chip to build sensitive unit of LAPS system.
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