AI Article Synopsis
- Researchers conducted phantom and mouse experiments to test a new method called the total light approach in time-domain fluorescence tomography, which speeds up the calculations for light propagation.
- They used cylindrical phantoms with indocyanine green (ICG) solutions to obtain time-resolved temporal profiles, achieving a spatial resolution of about 10 mm in the reconstructed images of ICG concentrations.
- The method also worked in vivo with a mouse, showing accurate ICG distribution under the skin, although some artifacts from autofluorescence were noted near the skin area.
Article Abstract
Phantom and mouse experiments of time-domain fluorescence tomography were conducted to demonstrate the total light approach which was previously proposed by authors. The total light approach reduces the computation time to solve the forward model for light propagation. Time-resolved temporal profiles were acquired for cylindrical phantoms having single or double targets containing indocyanine green (ICG) solutions. The reconstructed images of ICG concentration reflected the true distributions of ICG concentration with a spatial resolution of about 10 mm. In vivo experiments were conducted using a mouse in which an ICG capsule was embedded beneath the skin in the abdomen. The reconstructed image of the ICG concentration again reflected the true distribution of ICG although artifacts due to autofluorescence appeared in the vicinity of the skin. The effectiveness of the total light approach was demonstrated by the phantom and mouse experiments.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617724 | PMC |
| http://dx.doi.org/10.1364/BOE.4.000635 | DOI Listing |
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