AI Article Synopsis
- This study aimed to evaluate the effectiveness of Mastergraft(®) Strip combined with bone marrow aspirate (BMA) as a bone graft extender in a rabbit model for spine fusion.
- The research involved 36 rabbits undergoing lumbar intertransverse fusions, with three different treatment groups being analyzed for bone fusion success.
- Results showed that the Mastergraft(®) groups had promising fusion rates comparable to traditional autograft methods, indicating potential for improved bone healing without significant adverse effects.
Article Abstract
Study Design/setting: Randomized, controlled study in a laboratory setting. Blinded observations/assessment of study outcomes.
Objective: The Purpose of this study is to determine the performance characteristics of Mastergraft(®) Strip with bone marrow aspirate (BMA) as a bone graft extender in a rabbit posterolateral spine fusion model.
Summary Of Background Data: The rabbit posterolateral fusion model is an established environment for testing of fusion concepts. It offers the opportunity to obtain radiographic, histological, and biomechanical data on novel fusion materials.
Methods: Thirty six rabbits were entered into the study with 34 used for analysis. Bilateral posterolateral lumbar intertransverse fusions were performed at L5-L6. the lateral two thirds of the transverse processes were decorticated and covered with graft material: autograft only (2.5 - 3.0 cc/side), 75% Mastergraft(®) Strip + 5.0 cc BMA / 25% autograft (3.0 cc total per side), or 50% Mastergraft(®) Strip + 5.0cc BMA and 50% autograft (3.0 cc total per side). Animals were humanely euthanized at 8 weeks post surgery.
Results: The autograft group had a 60% radiographic fusion rate (6/10) and a manual palpation fusion rate of 50% (5/10). the 50% Mastergraft(®) Strip group had a 75% radiographic and manual palpation fusion rate (9/12). the 75% Mastergraft(®) Strip group demonstrated a 58% (7/12) radiographic and manual palpation fusion rate. Histologically, no adverse inflammatory reactions of significant size were present. The two Mastergraft(®) Strip groups demonstrated a tendency towards more bone development across the fusion bed.
Conclusions: In this commonly used rabbit posterolateral fusion model, Mastergraft(®) Strip with BMA in an autograft extender mode produces biomechanical and radiographic results similar to autograft fusion alone.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565416 | PMC |
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