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Collaborating with the enemy: function of macrophages in the development of neoplastic disease. | LitMetric

AI Article Synopsis

  • - Neoplastic cells alter immune system activity by releasing mediators like cytokines and chemokines, leading to reduced effectiveness of the immune response against tumors and promoting tumor growth and survival.
  • - The immune suppression and tolerance to tumor antigens are largely driven by macrophages, which can inhibit T lymphocyte responses and promote processes that aid tumor progression, such as angiogenesis and metastasis.
  • - Tumor-associated macrophages (TAMs) play a crucial role in supporting cancer development, working alongside tumor cells to enhance their proliferation and help them evade the immune system.

Article Abstract

Due to the profile of released mediators (such as cytokines, chemokines, growth factors, etc.), neoplastic cells modulate the activity of immune system, directly affecting its components both locally and peripherally. This is reflected by the limited antineoplastic activity of the immune system (immunosuppressive effect), induction of tolerance to neoplastic antigens, and the promotion of processes associated with the proliferation of neoplastic tissue. Most of these responses are macrophages dependent, since these cells show proangiogenic properties, attenuate the adaptive response (anergization of naïve T lymphocytes, induction of Treg cell formation, polarization of immune response towards Th2, etc.), and support invasion and metastases formation. Tumor-associated macrophages (TAMs), a predominant component of leukocytic infiltrate, "cooperate" with the neoplastic tissue, leading to the intensified proliferation and the immune escape of the latter. This paper characterizes the function of macrophages in the development of neoplastic disease.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613099PMC
http://dx.doi.org/10.1155/2013/831387DOI Listing

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