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Application of the new PRINTO classification criteria for juvenile idiopathic arthritis in a sample of Portuguese patients.
ARP Rheumatol
April 2024
Pediatric and Young Adult Rheumatology Unit, Pediatrics Department, Centro Hospitalar Universitário São João, Porto; Faculty of Medicine, University of Porto, Portugal.
Background: The International League of Associations for Rheumatology (ILAR) classification system for juvenile idiopathic arthritis (JIA) does not depict homogenous subgroups of disease. As to unify our language with the adult rheumatic diseases, the Pediatric Rheumatology International Trials Organization (PRINTO) is attempting to revise these criteria.
Objective: To reclassify a JIA sample according to the new provisional PRINTO subsets: systemic JIA (sJIA), RF-positive JIA (RF-JIA), early-onset ANA-positive JIA (eoANA-JIA), enthesitis/spondylitis-related JIA (ESR-JIA), "other JIA" and "unclassified JIA".
Assessment of quality of life and physical activity in patients with oligoarticular juvenile idiopathic arthritis in remission.
Eur J Pediatr
February 2024
Department of Pediatric Rheumatology, Ankara City Hospital, University of Health Sciences, Ankara, Turkey.
The purpose of this study was to evaluate physical activity (PA) and health-related quality of life (HRQOL) in children with oligoarticular juvenile idiopathic arthritis (JIA) in remission in comparison with healthy peers and to determine the disease-related factors affecting PA levels. This study was conducted with 50 oligoarticular JIA patients in remission and 50 healthy peers between 9 and 14 years. Demographic and clinical characteristics, laboratory parameters, and treatments were noted from electronic medical records.
View Article and Find Full Text PDFIdentification of key biomarkers in RF-negative polyarticular and oligoarticular juvenile idiopathic arthritis by bioinformatic analysis.
Pediatr Rheumatol Online J
November 2023
Department of Rheumatology and Immunology, Children's Hospital of Chongqing Medical University, Chongqing, 400010, China.
Objective: Juvenile idiopathic arthritis (JIA) is a broad term used to describe arthritis of unknown origin. JIA commonly persists into adulthood, often causing substantial morbidity such as restricted joint function, which can lead to challenges in employment and independence. This study aims to identify diagnostic biomarkers and investigate the role of immune cells in the pathogenesis of rheumatoid factor-negative polyarticular juvenile idiopathic arthritis (RF-negative pJIA) and oligoarticular juvenile idiopathic arthritis (oJIA).
View Article and Find Full Text PDFIs tear proteome profile a predictor of developing uveitis in ANA-positive patients with oligoarticular juvenile idiopathic arthritis?
Graefes Arch Clin Exp Ophthalmol
January 2024
Department of Pediatrics, Division of Pediatric Rheumatology, Kocaeli University Faculty of Medicine, Kocaeli, Turkey.
Article Synopsis
- The study focuses on the need for better biomarkers to assess the risk of uveitis in patients with oligoarticular juvenile idiopathic arthritis (oJIA), as current methods are limited.
- Tear samples from both oJIA patients without uveitis and those with uveitis were analyzed using advanced protein identification techniques.
- The analysis found that out of 15 common proteins identified, 10 were upregulated and 2 downregulated in uveitis patients, with cystatin-S showing the highest increase, indicating its potential as a key biomarker.
Predictors of relapse in patients with oligoarticular juvenile idiopathic arthritis in remission off medication.
Eur J Pediatr
October 2023
Division of Pediatric Rheumatology, Department of Pediatrics, University of Health Sciences, Ankara City Hospital, 06800, Bilkent, Ankara, Turkey.
The aim of this study was to evaluate the predictors of relapse in patients with oligoarticular juvenile idiopathic arthritis (oJIA) who achieved clinical remission off medication. This retrospective observational study was conducted between June 2009 and July 2022 in 126 patients with oJIA who achieved remission off medication. The relationships between relapse status and demographic, clinical and laboratory findings, and treatment details were evaluated using electronic medical records.
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