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Targeting CCR5: A central approach to HIV treatment and cure strategies.
Virology
December 2024
Section of Infectious Diseases, Department of Internal Medicine, Yale University, New Haven, CT, United States. Electronic address:
CCR5, a co-receptor critical for R5-tropic HIV entry into host cells, remains a key target for therapeutic interventions. HIV utilizes CCR5, expressed on T cells and macrophages, to facilitate viral entry. Genetic variants, such as the CCR5Δ32 homozygous mutation that confers protection to HIV infection, have made CCR5 a main target for gene-editing technologies, small-molecule inhibitors, and monoclonal antibody-based therapies.
View Article and Find Full Text PDFThe anaemia battle: Strategies for adolescent women's health in India.
J Family Med Prim Care
November 2024
Department of Community Medicine, Dr. D. Y. Patil Medical College, Hospital and Research Center, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India.
The Impact of HPV Vaccination on Cervical Cancer in adolescent females: A narrative review.
J Family Med Prim Care
November 2024
Department of Community Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India.
To effectively prevent cervical cancer, a leading cause of global morbidity and mortality among women, widespread adoption of the HPV vaccine has a well-established link to human papillomavirus (HPV) infection. HPV vaccine must be the vaccine's effectiveness in reducing HPV infections, and subsequent cervical lesions have been extensively demonstrated, marking a pivotal milestone in public health. Important research highlights the vaccine's safety profile, allaying worries and promoting trust in its application.
View Article and Find Full Text PDFPerformance of Ertapenem-Supplemented MacConkey Agar (MacErt) for Detecting Carbapenemase-Producing Enterobacterales.
Cureus
November 2024
Epidemiology and Public Health, Faculty of Medicine, Pharmacy, and Odonto-Stomatology, Université Cheikh Anta Diop de Dakar, Dakar, SEN.
Background and objectives Antimicrobial resistance (AMR) is a growing global threat, with carbapenemase-producing Enterobacterales (CPEs) representing a critical public health challenge. Rapid and accurate detection of CPEs is essential for controlling fatal bacterial AMR infections. This study evaluated the performance of MacConkey media supplemented with ertapenem (MacErt1 and MacErt2) for the detection of CPEs.
View Article and Find Full Text PDFKnowledge, Attitudes, and Practices Regarding COVID-19 Vaccination Among Internally Displaced People in the Kurdistan Region of Iraq (KRG).
Mater Sociomed
January 2024
Faculty of Medicine, Iuliu Haţieganu University of Medicine and Pharmacy Cluj-Napoca, Romania.
Background: Iraq has yet to establish and initiate any vaccination initiatives to address the ongoing COVID-19 outbreak and mitigate its spread and mortality.
Objective: This study aimed to evaluate the existing knowledge, attitudes, and behaviors surrounding COVID-19 vaccination amid the third wave of the outbreak.
Methods: This cross-sectional study utilized an anonymous online questionnaire, modeled after a study conducted in Bosnia and Herzegovina, to investigate COVID-19 vaccination attitudes and practices during the third wave of the outbreak in the country.
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