Fertility after ovarian and peritoneal endometriosis experimentally induced has been studied. The fertility rate in the animals with ovarian endometriosis was decreased of 40% and the same reduction was found in the animals with peritoneal endometriosis. Not only the direct effect from adhesion formation, but also changes in the peritoneal fluid or its constituents are proposed as causes of endometriosis-associated infertility.
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Front Med (Lausanne)
January 2025
Department of Surgery, School of Medicine, Nazarbayev University, Astana, Kazakhstan.
Background: Endometriosis is a condition affecting reproductive-age women and associated with dysmenorrhea, pelvic organs dysfunction, pelvic pain, and infertility. The real epidemiology of endometriosis remains underestimated. No data are available on prevalence of endometriosis in Kazakhstan.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Gynaecology, Xianning Central Hospital, The First Affiliated Hospital of Hubei University of Science and Technology, 228 Jingui Road, Xianan District, Xianning, 437100, China.
Dietary factors have recently been recognized as potentially influential in the pathogenesis of endometriosis (EM), yet studies on the causal relationship between dietary preferences and EM are limited. The present study aimed to explore the causal relationships between 187 dietary preferences and EM using Mendelian randomization (MR) methods. This study utilised genome-wide association study data from over 500,000 European participants for dietary preferences and 64,658 EM patients from Finland.
View Article and Find Full Text PDFJCI Insight
January 2025
Division of Environmental Genetics and Molecular Toxicology, University of Cincinnati College of Medicine, Cincinnati, United States of America.
Endometriosis is a chronic gynecological disease that affects 1 in 10 reproductive-aged women. Most studies investigate established disease; however, the initiation and early events in endometriotic lesion development remain poorly understood. Our study used neutrophils from human menstrual effluent from subjects with and without endometriosis for immunophenotyping, and a mouse model of endometriosis and a mouse endometriosis cell line to determine the role of neutrophils in the initiating events of endometriosis, including attachment and survival of minced endometrial pieces.
View Article and Find Full Text PDFCureus
December 2024
Department of Radiology, Souss Massa University Hospital Center, Faculty of Medicine and Pharmacy, Ibn Zohr University, Agadir, MAR.
Endometrioma is a localized form of endometriosis, usually found within the ovaries bilaterally, containing degenerated blood products resulting from bleeding of ectopic endometriotic tissue at different ages. Rupture of the endometrioma is a rare complication that may result in hemoperitoneum and peritonitis and thus presents similarly to other more common abdominal emergencies, and the concomitant presence of a ruptured endometrioma and another abdominal emergency, although exceptional, remains possible. Ultrasonography and sectional imaging can be used to assess a diagnosis that is often confirmed postoperatively.
View Article and Find Full Text PDFJ Hum Reprod Sci
December 2024
Department of Obstetrics and Gynaecology, Reproductive Health Research Centre, Alzahra Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Background: An increasing number of studies have demonstrated that excessive proliferation and apoptosis play a pivotal role in the development of endometriosis.
Aim: The aim of the study was to evaluate the expression of long non-coding RNA (lncRNA) FAS-AS1, FAS, soluble Fas (sFas) and caspase-3 in patients with different stages of endometriosis.
Setting And Design: The design of the study was a cross-sectional study.
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