AI Article Synopsis
- Chronic lymphocytic leukemia (CLL) is the most prevalent type of leukemia in adults in Western countries, and there is a need for new prognostic indicators for its variable clinical course.
- CD74, a protein involved in B cell growth and survival, was evaluated for its expression in CLL patients, revealing significantly higher levels compared to healthy controls and a correlation with other prognostic factors like ZAP70.
- The study found that high CD74 expression was associated with more advanced disease stages but showed no correlation with factors like sex, IgVH mutation status, or time to initial treatment.
Article Abstract
Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults in Western countries. It is characterized by heterogeneous clinical course of the disease and new prognostic factors are still needed. CD74 plays an important role in signal transduction in B cell proliferation and survival pathway. CD74 expression has been shown in solid tumors and has been connected with poor prognosis and tumor progression. The aim of the study was to evaluate the expression of CD74 in chronic lymphocytic leukemia patients with combination with other known prognostic factors. Expression of CD74 was determined in 90 patients and 28 healthy controls. CD74 expression was significantly higher in CLL group than in controls. There was positive correlation between CD74 and ZAP70 expression (p = 0.008). High expression of CD74 was positively correlated with more advanced stage of the disease (p = 0.02). No correlation was shown between CD74 and sex, mutational status IgVH and time to first treatment.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667374 | PMC |
| http://dx.doi.org/10.1007/s12032-013-0560-5 | DOI Listing |
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