Synthesis of 1,5-triazole bridged vancomycin CDE-ring bicyclic mimics using RuAAC macrocyclization.

Chem Commun (Camb)

Medicinal Chemistry & Chemical Biology, Utrecht Institute for Pharmaceutical Sciences, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands.

Published: May 2013

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Article Abstract

Herein we report the Ru(II)-catalyzed double-macrocyclization of a hexapeptide to obtain a mimic of the bicyclic CDE-ring of vancomycin, followed by measurement of its binding affinity for small peptide ligands using ITC.

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Source
http://dx.doi.org/10.1039/c3cc40628hDOI Listing

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