The purpose of this intervention study was to measure the impact of an onsite and online 12-week worksite heart-health campaign designed to reduce metabolic risk factors for employees at BMW of North America, LLC. All participants received three coaching sessions by a registered dietitian (RD), participated in eight educational sessions led by an RD, viewed their pre, midpoint and final biometric data online, and had access to other web-based tools and educational booklets. The program used team-based competition. At baseline and week 12, blood pressure, anthropometric and hematologic parameters were measured, including changes in weight, blood pressure, fasting blood glucose, waist circumference, total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, and smoking habits. Of the 100 individuals that enrolled, 95 completed the program, and 87 met criteria to be eligible for data analysis. Paired t tests demonstrated significant reductions in weight (p<.0001), body mass index (p=.0047), waist circumference (p <.0001), diastolic blood pressure (p=.0018), and systolic blood pressure (p=.0012). Paired t tests for total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, and fasting blood glucose did not indicate any significant improvements. There was an improvement in body mass index and blood pressure classifications after completion of the program. A Friedman's test of blood pressure classification demonstrated significant improvements in participants' blood pressure classification from pre-program to midpoint, midpoint to end, and pre-program to end. These results support the effectiveness of a dietitian-led, team-based, worksite heart-health campaign with web-based education to reduce risk factors for metabolic syndrome.
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http://dx.doi.org/10.5210/ojphi.v4i2.4005 | DOI Listing |
Chem Res Toxicol
January 2025
School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, Zhejiang, P.R. China.
Apatinib, a commonly used tyrosine kinase inhibitor in cancer treatment, can cause adverse reactions such as hypertension. Hypertension, in turn, can increase the risk of certain cancers. The coexistence of these diseases makes the use of combination drugs more common in clinical practice, but the potential interactions and regulatory mechanisms in these drug combinations are poorly understood.
View Article and Find Full Text PDFCancer Med
January 2025
Department of Pharmacology, College of Pharmacy, Jinan University, Guangzhou, China.
Background: Distinctive heterogeneity characterizes diffuse large B-cell lymphoma (DLBCL), one of the most frequent types of non-Hodgkin's lymphoma. Mitochondria have been demonstrated to be closely involved in tumorigenesis and progression, particularly in DLBCL.
Objective: The purposes of this study were to identify the prognostic mitochondria-related genes (MRGs) in DLBCL, and to develop a risk model based on MRGs and machine learning algorithms.
J Agric Food Chem
January 2025
Fujian Engineering Research Center for Green Pest Management/Fujian Key Laboratory for Monitoring and Integrated Management of Crop Pests/East China Branch of the National Center for Agricultural Biosafety Sciences, Institute of Plant Protection, Fujian Academy of Agricultural Sciences, Fuzhou 350013, China.
Azole and benzimidazole fungicides are widely used agrochemicals to prevent and treat fungal growth and are frequently detected in aquatic environments. Here, we aimed to assess the aquatic ecological risks of ten currently used azole and benzimidazole fungicides, which with the aryl hydrocarbon receptor (AhR) agonistic activity, and their transformation products (TPs). We obtained over 400 types of aerobic TPs for ten fungicides.
View Article and Find Full Text PDFJACC Adv
January 2025
Professor of Clinical Medicine, Division of Endocrinology, Diabetes and Metabolism, Weil Cornell Medicine-New York Presbyterian, New York, New York, USA.
JACC Adv
January 2025
Department of Endocrinology Medicine, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Background: Early-onset ischemic heart disease (IHD) is a growing burden associated with high disability and death.
Objectives: This study aimed to estimate the burden of incidence, prevalence, and disability-adjusted life years (DALY) of early-onset IHD from 1990 to 2019.
Methods: Data on the burden of early-onset IHD (men<55 years, women<65 years), including prevalence, incidence, DALY, and deaths, were collected from the Global Burden of Disease study for 204 countries and territories from 1990 to 2019.
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