Background: Ecballium elaterium (also known as squirting cucumber in the Mediterranean countries) is a weedy plant that belongs to the Cucurbitacea family. The roots and juice of its fruits were used traditionally against a wide range of diseases and symptoms, since it was known for its anti-inflammatory and analgesic effects. The use of the extract, though, has been linked to allergic reactions and toxic effects. In this report, we present a case of severe uvular edema and hypoxemia due to a single use of Ecballium elaterium extract, and we discuss the possibility of life-threatening conditions resulting from the utilization of this particular plant as a remedy.
Case Report: A male Caucasian presented to the ER with complaints of troubled breathing and retrosternal discomfort that started a few hours before arriving at the ER. The patient's medical history revealed the use of Ecballium elaterium extract. Clinical examination confirmed severe uvular edema and hypoxemia. Administration of oxygen and IV drugs (Hydrocortisone) relieved the symptoms and improved the patient's condition. After a 24-hour hospitalization the patient was discharged without further complaints.
Conclusions: The use of Ecballium elaterium extract as a remedy can cause severe adverse effects that should not be ignored. Uvular edema is one of the most common and can lead, as shown above, to hypoxemia, which is a potentially life-threatening condition.
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http://dx.doi.org/10.12659/AJCR.882292 | DOI Listing |
Food Chem
December 2024
Dipartimento di Chimica; Centro Interdipartimentale SMART.
Plant metabolites known as cucurbitacins are known to impart an unpleasant bitter taste to edible fruits and even lead to severe health complications after the ingestion of relatively high amounts. In this study, an analytical method based on reversed phase liquid chromatography with combined detection by UV spectroscopy and atmospheric pressure chemical ionization high-resolution single/tandem mass spectrometry was applied to confirm the occurrence of four cucurbitacins (B, D, and R, and 23,24-dihydro cucurbitacin B) previously inferred in unexpectedly bitter-tasting fruits of an Italian variety (Scopatizzo) of unripe melon (Cucumis melo L.), known for the sweetness of its fruits.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
December 2024
University of Oxford Botanic Garden, Oxford OX1 4AZ, United Kingdom.
Rapid movement is rare in the plant kingdom, but a prerequisite for ballistic seed dispersal. A particularly dramatic example of rapid motion in plants is the squirting cucumber () which launches its seeds explosively via a high-pressure jet. Despite intriguing scientists for centuries, the exact mechanism of seed dispersal and its effect on subsequent generations remain poorly understood.
View Article and Find Full Text PDFMolecules
September 2024
Department of Agricultural Sciences, Università di Napoli Federico II, Via Università 100, 80055 Portici, NA, Italy.
, also known as squirting cucumber, is a plant which is widespread in temperate regions of Europe, Africa and Asia. The plant is considered to be one of the oldest used drugs. In the last decades, has been widely studied as a source of triterpene metabolites named cucurbitacins, often found as glycosylated derivatives, used by the plant as defensive agents.
View Article and Find Full Text PDFNat Mater
October 2024
Department of Mechanical and Automation Engineering, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.
Robotic tasks that require robust propulsion abilities such as jumping, ejecting or catapulting require power-amplification strategies where kinetic energy is generated from pre-stored energy. Here we report an engineered accumulated strain energy-fracture power-amplification method that is inspired by the pressurized fluidic squirting mechanism of Ecballium elaterium (squirting cucumber plants). We realize a light-driven hydrogel launcher that harnesses fast liquid vapourization triggered by the photothermal response of an embedded graphene suspension.
View Article and Find Full Text PDFSteroids
October 2023
Department of Medical Biochemistry, Faculty of Medicine, Inonu University, Malatya, Turkey.
Objective: Cucurbitacin E (CuE), a natural compound found in medicinal plants such as Ecballium Elaterium, has demonstrated antiproliferative and apoptotic effects in various cancer cell types due to its tetracyclic triterpenoid structure. Sorafenib, a multi-tyrosine kinase inhibitor, is commonly used in hepatocellular carcinoma (HCC) treatment. This study aimed to investigate the anticancer effect of CuE alone and in combination with sorafenib on HepG2 cells.
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