Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00204-013-1055-z | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Tumorigenesis Caused by Aberrant Expression of GANP, a Central Component in the Mammalian TREX-2 Complex-Lessons from Transcription-Coupled DNA Damages.
Int J Mol Sci
December 2024
Department of Diagnostic Pathology and Genome Medical Center, Kindai University Hospital, Osaka-sayama 589-8511, Osaka, Japan.
DNA is frequently damaged by genotoxic stresses such as ionizing radiation, reactive oxygen species, and nitrogen species. DNA damage is a key contributor to cancer initiation and progression, and thus the precise and timely repair of these harmful lesions is required. Recent studies revealed transcription as a source of genome instability, and transcription-coupled DNA damage has been a focus in cancer research.
View Article and Find Full Text PDFConsensus findings of an International Workshops on Genotoxicity Testing workshop on using transcriptomic biomarkers to predict genotoxicity.
Environ Mol Mutagen
January 2025
Department of Biology, University of Ottawa, Ottawa, Ontario, Canada.
Article Synopsis
- Gene expression biomarkers can help identify both genotoxic and non-genotoxic carcinogens, which could reduce the need for animal testing.
- In August 2022, a workshop reviewed current methods for using transcriptomic profiling to detect genotoxic chemicals, examining 1341 papers to find reliable biomarkers.
- The analysis identified two promising in vivo biomarkers and three in vitro biomarkers that show over 92% predictive accuracy and can be adapted for various testing conditions, with support from workshop participants for their regulatory adoption.
Food Safety Evaluation of Recombinant Humanized Type III Collagen Produced by Komagataella phaffii SMD1168-2COL3.
J Appl Toxicol
January 2025
College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.
Collagens are biofunctional proteins that have been widely used in many fields, including biomedical, cosmetics, and skin care for their value in maintaining the integrity of cellular membranes. Collagens are also commonly consumed in foods and provide a source of protein and amino acids. As part of the safety assessment for this particular recombinant humanized type III (RHTypeIII) collagen produced by Komagataella phaffii SMD1168-2COL3, a series of toxicological tests were conducted.
View Article and Find Full Text PDFBeyond the virus: ecotoxicological and reproductive impacts of SARS-CoV-2 lysate protein in C57Bl/6j female mice.
Environ Sci Pollut Res Int
January 2025
Post-Graduation Program in Ecology, Conservation, and Biodiversity, Federal University of Uberlândia, Uberlândia, MG, 38408144, Brazil.
Since the establishment of the COVID-19 pandemic, a range of studies have been developed to understand the pathogenesis of SARS-CoV-2 infection, vaccine development, and therapeutic testing. However, the possible impacts that these viruses can have on non-target organisms have been explored little, and our knowledge of the consequences of the COVID-19 pandemic for biota is still very limited. Thus, the current study aimed to address this knowledge gap by evaluating the possible impacts of oral exposure of C57Bl/6 J female mice to SARS-CoV-2 lysate protein (at 20 µg/L) for 30 days, using multiple methods, including behavioral assessments, biochemical analyses, and histopathological examinations.
View Article and Find Full Text PDFMachine learning enhances genotoxicity assessment using MultiFlow® DNA damage assay.
Environ Mol Mutagen
December 2024
Research and Development, Preclinical Safety, Sanofi, Industriepark Hoechst, Frankfurt am Main, Germany.
Genotoxicity is a critical determinant for assessing the safety of pharmaceutical drugs, their metabolites, and impurities. Among genotoxicity tests, mechanistic assays such as the MultiFlow® DNA damage assay (MFA) allows the investigations on mode of action (MoA) of DNA damage through four mechanistic markers recorded at two time points. Previous studies have shown that machine learning (ML) can enhance precision on classifying the MoA of genotoxicants.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!