The effects of varying degrees of hypoxia on sleep-wake organization were studied in rats prepared for chronic electrophysiological recording. The influence of Piracetam (75, 50, and 500 mg/kg, i.p.) and Hydergine (0.5, 1, and 3 mg/kg, i.p.) on sleep-wake organization in 10.5% oxygen was also investigated. The sleep-wake organization of rats under the effect of 15.5% oxygen content was unchanged, compared to that of normoxic control. More extreme hypoxia (12.6 and 10.5% oxygen) produced dramatic changes in sleep organization without influencing gross behavior. Paradoxical sleep (PS) stages became less frequent and shortened and were totally absent in 10.5% oxygen. Frequent wakings caused disturbed and superficial sleep. Central biochemical mechanisms, peripheral chemoreceptor reflex pathways and, as a consequence, decrease of duration of deep sleep periods, may contribute to the development of hypoxic sleep disturbances. Piracetam alleviated and Hydergine moderately reversed the hypoxic sleep disturbance.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Overcoming Recurrent Isolated Sleep Paralysis: A Case Report of Integrative Management With Yoga, Meditation, and Vitamin D3 Supplementation.
Cureus
December 2024
Community Medicine, Terna Medical College, Navi Mumbai, IND.
Recurrent isolated sleep paralysis (RISP) is a rare but distressing condition characterized by episodes of temporary immobility during transitions between wakefulness and sleep. This report describes a 30-year-old female presenting frequently with nightmares, sleep paralysis, and associated stress, successfully managed with a holistic approach incorporating yoga, meditation, chanting, and vitamin D3 supplementation. The patient's significant history of osteoporosis (in February 2019, bone density T-score <-2.
View Article and Find Full Text PDFOccupational burnout during war: The role of stress, disruptions in routine, sleep, work-family conflict, and organizational support as a moderator.
PLoS One
January 2025
School of Behavioral Sciences, The Academic College of Tel Aviv-Yafo, Tel Aviv, Israel.
Background: Occupational burnout, resulting from long-term exposure to work-related stressors, is a significant risk factor for both physical and mental health of employees. Most research on burnout focuses on routine situations, with less attention given to its causes and manifestations during prolonged national crises such as war. According to the Conservation of Resources theory, wartime conditions are associated with a loss of resources, leading to accelerated burnout.
View Article and Find Full Text PDFTest-retest reliability of the Arabic version of the Pittsburgh Sleep Quality Index.
Medicine (Baltimore)
January 2025
Department of Medical Education, College of Medicine, Imam Mohammad Ibn Saud Islamic University, Riyadh, Saudi Arabia.
This study aimed to assess the test-retest reliability and validity of the Arabic version of the Pittsburgh Sleep Quality Index (A-PSQI), a 19-item sleep evaluation tool, in a population of medical students and interns in Saudi Arabia. Following a 16-person pilot study, 202 participants completed 2 A-PSQI questionnaires with a 2-week test-retest interval to avoid a carryover effect. Statistical analysis using RStudio included Cronbach alpha, Spearman rank correlation, and the intraclass correlation coefficient (ICC).
View Article and Find Full Text PDFAn analysis of self-reported sleep disturbance from nighttime wind turbine noise suggests minimal effects but highlights the need for standardization in research designa).
J Acoust Soc Am
January 2025
Health Canada, Consumer and Clinical Radiation Protection Bureau, Non-Ionizing Radiation Health Sciences Division, Ottawa, Ontario K1A 1C1, Canada.
The World Health Organization Environmental Noise Guidelines provide source-based nighttime sound level (Lnight) recommendations. For non-aircraft sources, the recommended Lnight is where the absolute prevalence of high sleep disturbance (HSD) equals 3%. The Guideline Development Group did not provide an Lnight for wind turbines due to inadequate data.
View Article and Find Full Text PDFEffect of fezolinetant on patient-reported quality-of-life outcomes: Data from a phase 3b study (DAYLIGHT) of the treatment of moderate to severe vasomotor symptoms associated with menopause in women considered unsuitable for hormone therapy.
Maturitas
February 2025
Hormone Hamburg, Hamburg, Germany. Electronic address:
Objective: To report patient-reported quality-of-life (QOL) outcomes in the DAYLIGHT study.
Study Design: DAYLIGHT was a phase 3b, randomized, double-blind, 24-week, placebo-controlled study. Participants were women aged ≥40 to ≤65 years with moderate to severe vasomotor symptoms (VMS) considered unsuitable for hormone therapy (HT) (contraindications, caution, stoppers, or averse) randomized 1:1 to placebo or fezolinetant 45 mg once daily.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!