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US Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA.
Published: May 2013
AI Article Synopsis
A study investigated genetic loci linked to extreme body measurements such as BMI, height, and waist-to-hip ratio in a large sample of over 263,000 individuals of European descent.
Researchers discovered 4 new genetic loci related to height and 7 new loci associated with obesity classes by comparing the highest and lowest 5th percentiles of these traits.
The findings indicate that the genetic variations identified in extreme traits largely reflect those present in the general population, with minimal differences across various obesity subgroups.
Article Abstract
Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups.
