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Arylsulfonamide pyrimidines as VLA-4 antagonists. | LitMetric

AI Article Synopsis

Article Abstract

A series of (S)-2-(2-(diethylamino)-5-(N-alkyl-N-sulfonamido)pyrimidin-4-ylamino)-3-(4-(carbamoyloxy)phenyl)propanoic acid is discovered as orally available VLA-4 antagonists. Representative compounds 11b and 11p showed efficacy in multiple in vivo animal models. The in vitro selectivity of 11p is also described.

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Source
http://dx.doi.org/10.1016/j.bmcl.2013.03.010DOI Listing

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