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Patient-centered outcomes for clinical trials in chronic rhinosinusitis with or without nasal polyps and allergic fungal rhinosinusitis.
J Patient Rep Outcomes
January 2025
Sanofi US Services, Inc., Bridgewater, NJ, USA.
Background: Chronic rhinosinusitis (inclusive of subtypes with nasal polyps [CRSwNP], without nasal polyps [CRSsNP], and allergic fungal rhinosinusitis [AFRS]) causes inflammation of the nose mucosa and paranasal sinuses. Unfortunately, evidence supporting use of clinical outcome assessments (COAs) in regulated clinical trials to assess key measurement concepts of these conditions is limited.
Objective: To identify key disease-related symptoms and impacts, potential outcomes of interest for new treatments, and COAs available to measure those outcomes among adult and adolescent individuals living with CRSwNP, CRSsNP, and AFRS.
Arthroscopic Bone Grafting of Deep Acetabular Cysts in Hip Preservation Surgery: A Matched Case-Control Study.
Orthop J Sports Med
January 2025
Department of Orthopedics, School of Medicine, University of Colorado, Aurora, Colorado, USA.
Background: Acetabular subchondral cysts are commonly identified signs of joint degeneration and arthritis. This pathology is generally considered a relative contraindication for hip preservation surgery.
Purpose: To investigate the effect of arthroscopic bone grafting for the treatment of acetabular subchondral cysts.
Drivers and barriers to the choice of production systems among smallholder pig farmers: Evidence from Northern Uganda.
Heliyon
January 2025
Department of Rural Development and Agribusiness, Faculty of Agriculture and Environment, Gulu University, P.O Box 166, Gulu, Uganda.
Pork consumption has risen significantly in many emerging nations, prompting diverse pig production systems. This study explored the drivers and barriers to the choices of pig production systems and the challenges confronting pig farmers in Northern Uganda. Data were collected from 240 pig farmers using a structured questionnaire and analyzed using multinomial logit regression.
View Article and Find Full Text PDFKnitted stockings were one of the most important early modern textile innovations. Especially fine stockings made of silk were a popular fashion product and one of the key novelties among European elites. The popularity of knitted stockings is seen in the fact that by the end of the fifteenth century, there were thousands of professional knitters in Europe.
View Article and Find Full Text PDFHow Often Does Bacteremia Occur in Patients With Chronic Periprosthetic Joint Infection? A Prospective, Observational Study.
Clin Orthop Relat Res
January 2025
Department of Orthopedics, First Affiliated Hospital of Xinjiang Medical University, Urumqi, PR China.
Background: Bacteremia is sometimes observed in patients with prosthetic joint infection (PJI), and it is associated with a lower likelihood of infection control. However, the prevalence and association of bacteremia in chronic PJI remain unknown.
Questions/purposes: (1) What percentage of patients are diagnosed with bacteremia at the time of hospital admission and before surgery for chronic PJI? (2) What clinical factors are associated with positive blood cultures? (3) To what degree are positive blood cultures associated with infection-free implant survival in patients with chronic PJI?
Methods: This prospective study was conducted at a single academic institution from June 2021 to August 2022.
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