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Electrospun nanofibers of curcumin/HP-beta-CD/pullulan complex with enhanced solubility and controlled release in food and drug delivery applications.
Int J Biol Macromol
January 2025
Division of Bioinspired Materials and Biosensor Technologies, Institute of Materials Science, Faculty of Engineering, Kiel University, 24143 Kiel, Germany; Kiel Nano, Surface and Interface Science (KiNSIS), Kiel University, 24118 Kiel, Germany. Electronic address:
Curcumin, a hydrophobic drug derived from the rhizome of Curcuma longa, exhibits significant bioactive properties, including antioxidant and antimicrobial potential. However, its poor water solubility and rapid degradation limit its practical applications. This study presents a novel design of electrospun nanofibers using Curcumin/hydroxypropyl-β-cyclodextrin inclusion complex (HP-β-CD-IC) combined with pullulan to enhance thermal stability and controlled release.
View Article and Find Full Text PDFInhibiting Friction-Induced Exogenous Adhesion via Robust Lubricative Core-Shell Nanofibers for High-Quality Tendon Repair.
Biomacromolecules
January 2025
Department of Hepatobiliary Surgery, Hebei International Joint Research Center for Digital Twin Diagnosis and Treatment of Digestive Tract Tumors, Baoding Key Laboratory of Precision Diagnosis and Treatment of Digestive Tract Tumors, Affiliated Hospital of Hebei University, Baoding 071000, China.
Friction is the trigger cause for excessive exogenous adhesion, leading to the poor self-repair of the tendon. To address this problem, we developed electrospun dual-functional nanofibers with surface robust superlubricated performance and bioactive agent delivery to regulate healing balance by reducing exogenous adhesion and promoting endogenous healing. Coaxial electrospinning and our previous developed in situ robust nanocoating growth techniques were employed to create the lubricative/repairable core-shell structured nanofibrous membrane (L/R-NM).
View Article and Find Full Text PDFDocosahexaenoic Acid-Infused Core-Shell Fibrous Membranes for Prevention of Epidural Adhesions.
Int J Mol Sci
December 2024
Department of Neurosurgery, Chang Gung Memorial Hospital, Linkou, Chang Gung University School of Medicine, Kwei-San, Taoyuan 33305, Taiwan.
Avoiding epidural adhesion following spinal surgery can reduce clinical discomfort and complications. As the severity of epidural adhesion is positively correlated with the inflammatory response, implanting a fibrous membrane after spinal surgery, which can act as a physical barrier to prevent adhesion formation while simultaneously modulates postoperative inflammation, is a promising approach to meet clinical needs. Toward this end, we fabricated an electrospun core-shell fibrous membrane (CSFM) based on polylactic acid (PLA) and infused the fiber core region with the potent natural anti-inflammatory compound docosahexaenoic acid (DHA).
View Article and Find Full Text PDFElectrospun scaffold with bioactive polyurethane shell infused with propolis and starch-hyaluronic acid core: An advanced therapeutic platform for skin tissue engineering.
Int J Biol Macromol
February 2025
Department of Electrical Engineering, South Tehran Branch, Islamic Azad University, Tehran, Iran.
Biological macromolecules such as polysaccharides and proteins, due to their excellent biocompatibility and biodegradability, are ideal for promoting Skin Tissue Engineering (STE) both in vitro and in vivo. In this study, a core-shell electrospun scaffold was fabricated using the coaxial electrospinning method, with Polyurethane (PU) forming the shell and a mixture of Starch (ST), Propolis Extract (PE), and Hyaluronic Acid (HA) forming the core. The scaffold's morphology was characterized by Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM), confirming the successful formation of a well-defined core-shell structure.
View Article and Find Full Text PDFCarbon Nanofiber/Polyaniline Composite Aerogel with Excellent Electromagnetic Interference Shielding, Low Thermal Conductivity, and Extremely Low Heat Release.
Nanomicro Lett
December 2024
Department of Materials Science and Engineering, Southern University of Science and Technology, Shenzhen, 518055, People's Republic of China.
The rapid development of communication technology and high-frequency electronic devices has created a need for more advanced electromagnetic interference (EMI) shielding materials. In response to this demand, a study has been conducted to develop multifunctional carbon nanofibers (CNFs)/polyaniline (PANI) aerogels with excellent electromagnetic interference shielding, flame retardancy, and thermal insulation performance. The process involved freeze-drying of electrospun CNFs and PANI nanoparticles followed by in situ growth PANI to coat the CNFs, creating the core-shell structured CNFs/PANI composite fiber and its hybrid aerogels (CP-3@PANI).
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