Background: Allergic reactions occur commonly in transfusion practice. However, severe anaphylactic reactions are rare; anti-IgA (IgA: Immunoglobulin A) in IgA-deficient patients is one of the well-illustrated and reported causes for such reactions. However, IgE-mediated hypersensitivity reaction through blood component transfusion may be caused in parasitic hyperimmunization for IgG and IgE antibodies.
Case Report: We have evaluated here a severe anaphylactic transfusion reaction retrospectively in an 18year-old male, a known case of cerebral malaria, developed after platelet transfusions. The examination and investigations revealed classical signs and symptoms of anaphylaxis along with a significant rise in the serum IgE antibody level and IgG by hemagglutination method. Initial mild allergic reaction was followed by severe anaphylactic reaction after the second transfusion of platelets.
Conclusion: Based on these results, screening of patients and donors with mild allergic reactions to IgE antibodies may help in understanding the pathogenesis as well as in planning for preventive desensitization and measures for safe transfusion.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613673 | PMC |
| http://dx.doi.org/10.4103/0973-6247.106748 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Evaluation of drug-related anaphylaxis in children: multi-center study.
Eur J Pediatr
March 2025
Pediatric Immunology and Allergy Department, Ankara Bilkent City Hospital, Ankara, Turkey.
The aim of the study is to elucidate demographic characteristics, risk factors, clinical presentations, causative agents, and management approaches pertaining to drug-related anaphylaxis in the paediatric population. This study is a multicenter retrospective study that included paediatric patients aged between 1 month and 18 years, who were admitted to the Pediatric Allergy and Immunology outpatient clinics of 11 participating centres with a presumptive diagnosis of drug-induced anaphylaxis, that fulfilled the standardised criteria for anaphylaxis, between January 2017 and December 2022. A total of 293 anaphylactic episodes presented among 265 patients, of which 48.
View Article and Find Full Text PDFDiagnosis and Management of Lipid Transfer Protein Allergy-A BSACI Clinical Practice Statement.
Clin Exp Allergy
March 2025
Department of Allergy and Clinical Immunology, Royal Brompton and Harefield Hospitals, Part of Guys and St Thomas NHS Foundation Trust, London, UK.
Although the most prevalent plant food allergy in the United Kingdom (UK) is pollen food syndrome (PFS), there is increasing evidence that reactions to plant foods could also be due to sensitisation to Lipid Transfer Proteins (LTP). These proteins, highly resistant to heat and processing, are present in raw, cooked and processed plant foods and often provoke moderate to severe symptoms. LTP allergy is common in Mediterranean countries, but there is a lack of epidemiological data from Northern Europe, although small case series have been published characterising LTP allergy in both England and Scotland.
View Article and Find Full Text PDFLong-term maintenance of mycophenolate mofetil in anti-NMDA receptor encephalitis (LEARN): a multicentre, open-label, blinded-endpoint, randomised controlled trial.
J Neurol Neurosurg Psychiatry
February 2025
Department of Neurology, West China Hospital of Sichuan University, Chengdu, Sichuan, China
Background: Anti-N-methyl-D-aspartate receptor encephalitis (NMDARE) is a severe autoimmune disorder with high morbidity and mortality. Current treatments have limitations including relapse, highlighting the need for effective maintenance therapy. This study evaluates the efficacy and safety of mycophenolate mofetil (MMF) as long-term adjunctive therapy to first-line treatment in newly diagnosed patients with NMDARE.
View Article and Find Full Text PDFAllergen immunotherapy-induced anaphylaxis: Data from the European Anaphylaxis Registry.
Ann Allergy Asthma Immunol
February 2025
Division of Allergy and Immunology, Department of Dermatology, Venerology and Allergy, Charité-Universitätsmedizin Berlin, Berlin, Germany. Electronic address:
Background: Data on anaphylaxis due to allergen immunotherapy (AIT) are limited. This study assessed AIT-induced anaphylaxis using data from the European Anaphylaxis Registry.
Objective: To analyze the characteristics, symptoms, severity, and emergency management of AIT-induced anaphylactic reactions across age groups and the administered allergenic source.
Anaphylactic shock induced by intravenous ketorolac: A case report.
Heliyon
February 2025
Department of Orthopedics and Traumatology, Southern Medical University Hospital of Integrated Traditional Chinese and Western Medicine, Guangzhou, China.
Ketorolac trometamol injection is the first injectable nonsteroidal anti-inflammatory drug (NSAID) approved for the short-term management of moderate to severe pain. As a non-opioid alternative, it represents a critical development for acute pain relief, particularly in postoperative and injury-related scenarios. Like other NSAIDs, ketorolac trometamol is associated with common adverse reactions such as dizziness, headache, drowsiness, nausea, and vomiting, which are generally mild to moderate.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!