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| http://dx.doi.org/10.1136/bcr-2013-008989 | DOI Listing |
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A Japanese case of Papillon-Lefèvre syndrome diagnosed by pyogenic liver abscess.
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Department of Laboratory Medicine, Division of Clinical Immunology, Karolinska Institutet, Huddinge, Stockholm, Sweden; Department of Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden. Electronic address:
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- The human peptide LL-37 can trigger autophagy in macrophages, but its effectiveness varies based on post-translational modifications (PTMs) and its cellular source.
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An uncontrolled activity of neutrophil serine proteases (NSPs) contributes to inflammatory diseases. Cathepsin C (CatC) is known to activate NSPs during neutrophilic differentiation and represents a promising pharmacological target in NSP-mediated diseases. In humans, Papillon-Lefèvre syndrome (PLS) patients have mutations in theirCTSC gene, resulting in the complete absence of CatC activity.
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View Article and Find Full Text PDFThe impact of general anesthesia versus non-general anesthesia on thrombectomy outcomes by occlusion location: insights from the ETIS registry.
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12Aristotle University of Thessaloniki, Ahepa Hospital, Thessaloniki, Greece.
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- The study investigates how different anesthesia techniques (general anesthesia vs. non-general anesthesia) affect outcomes in mechanical thrombectomy for stroke, with a focus on the location of the blood clot.
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