We present a visualization tool for the real-time analysis of interactively steered ensemble-simulation runs, and apply it to flooding simulations. Simulations are performed on-the-fly, generating large quantities of data. The user wants to make sense of the data as it is created. The tool facilitates understanding of what happens in all scenarios, where important events occur, and how simulation runs are related. We combine different approaches to achieve this goal. To maintain an overview, data are aggregated and embedded into the simulation rendering, showing trends, outliers, and robustness. For a detailed view, we use information-visualization views and interactive visual analysis techniques. A selection mechanism connects the two approaches. Points of interest are selected by clicking on aggregates, supplying data for visual analysis. This allows the user to maintain an overview of the ensemble and perform analysis even as new data are supplied through simulation steering. Unexpected or unwanted developments are detected easily, and the user can focus the exploration on them. The solution was evaluated with two case studies focusing on placing and testing flood defense measures. Both were evaluated by a consortium of flood simulation and defense experts, who found the system to be both intuitive and relevant.
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http://dx.doi.org/10.1109/TVCG.2012.175 | DOI Listing |
Retina
January 2025
Department of Ophthalmology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Purpose: To evaluate preoperative and early postoperative factors associated with changes in visual acuity in macula-off rhegmatogenous retinal detachment (RRD) patients.
Methods: A retrospective review of 59 eyes from 59 patients who underwent pars plana vitrectomy (PPV) and silicone oil (SiO) tamponade for macula-off RRD. Preoperative and early postoperative characteristics were analyzed using the classification and regression tree (CART) analysis.
J Interferon Cytokine Res
January 2025
Gansu University of Traditional Chinese Medicine, Lanzhou, China.
Interferon-gamma (IFN-γ) is an important cytokine associated with antitumor immunity and has been implicated in the pathogenesis and progression of lung cancer. Nevertheless, no bibliometric analyses have been published in this field to date, and thus we aim to address this gap in knowledge. A search of the Web of Science (WOS) for literature related to the treatment of lung cancer with IFN-γ was conducted from 2002 to 2024.
View Article and Find Full Text PDFJ Chem Inf Model
January 2025
Geneis (Beijing) Co. Ltd., Beijing 100102, China.
Identification of potential drug-target interactions (DTIs) is a crucial step in drug discovery and repurposing. Although deep learning effectively deciphers DTIs, most deep learning-based methods represent drug features from only a single perspective. Moreover, the fusion method of drug and protein features needs further refinement.
View Article and Find Full Text PDFActa Bioeng Biomech
June 2024
2Daping Hospital, Army Medical Center, Chongqing, China.
: This study explores how thoracic orientation affects lung pressure and injury outcomes from shock waves, building on earlier research that suggested human posture impacts injury severity. : A layered finite element model of the chest was constructed based on the Chinese Visual Human Dataset (CVH), including the rib and intercostal muscle layers. The dynamic response of the chest under 12 different angle-oriented shock waves under incident pressures of 200 kPa and 500 kPa was calculated.
View Article and Find Full Text PDFACS Chem Biol
January 2025
Biogen, Chemical Biology & Proteomics, 225 Binney Street, Cambridge, Massachusetts 02142, United States.
Dimethyl fumarate (DMF) is an established oral therapy for multiple sclerosis worldwide. Although the clinical efficacy of these fumarate esters has been extensively investigated, the mode of action and pharmacokinetics of fumarates have not been fully elucidated due to their broad-spectrum reactivity and complex metabolism in vivo. To better understand the mechanism of action of DMF and its active metabolite, monomethyl fumarate (MMF), we designed and utilized clickable probes to visualize and enrich probe-modified proteins.
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