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A multi-omics Mendelian randomization identifies putatively causal genes and DNA methylation sites for asthma.
World Allergy Organ J
December 2024
Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China.
Background: Asthma is a global chronic respiratory disease with complex pathogenesis. While current therapies offer some relief, they often fall short in effectively managing symptoms and preventing exacerbations for numerous patients. Thus, understanding its mechanisms and discovering new drug targets remains a pressing need for better treatment.
View Article and Find Full Text PDFAttendance rate and perceived relevance related to type, content, and delivery of current rehabilitation programmes after surgical resection for non-small cell lung cancer.
Front Rehabil Sci
December 2024
Pulmonary Research Unit (PLUZ), Department of Medicine, Zealand University Hospital Roskilde and Naestved, Naestved Hospital, Naestved, Denmark.
Background: Surgical resection is the preferred treatment for localised non-small cell lung cancer (NSCLC). Rehabilitation is central in the management of the associated impaired quality of life, high symptom burden, deconditioning, and social-existential vulnerability. Yet, optimal content and delivery of rehabilitation are not yet defined.
View Article and Find Full Text PDFAn Atypical Presentation of Osseous Choristoma in a 63-Year-Old Male: A Lesion Beyond the Common Demographic and Anatomical Norms.
Cureus
November 2024
Otolaryngology-Head and Neck Surgery, Freeman Health System, Joplin, USA.
Osseous choristomas, characterized by ectopic bone, are rare and typically found in the head and neck, particularly on the tongue. This report describes a unique case of an osseous choristoma in a 63-year-old male with an unusual posterior tongue location. An incidental base of tongue (BOT) mass was discovered during a bronchoscopy for lung biopsy.
View Article and Find Full Text PDFBilirubin nanoparticles modulate Treg/Th17 cells and functional metabolism of gut microbiota to inhibit lung adenocarcinoma.
Biochim Biophys Acta Mol Basis Dis
December 2024
Department of General Practice, The Third Xiangya Hospital of Central South University, 138 Tongzipo Road, Yuelu District, Changsha 410013, Hunan, China. Electronic address:
The level of serum bilirubin is associated with the incidence of lung cancer in both smokers and non-smokers, but the specific mechanism is unknown. Bilirubin nanoparticles (BRNPs) were synthesized to explore the effects on Treg/Th17 immunity and gut microbiota in Lewis Lung Carcinoma (LLC) mice, to provide insights for the treatment of lung adenocarcinoma. 10 μg/mL BRNPs promoted apoptosis of A549, NCI-H1299 and LLC cells.
View Article and Find Full Text PDFComparing standard treatment of moderate to severe obstructive sleep apnoea to add-on acetazolamide treatment: An open-label randomised controlled trial.
Lung India
January 2025
Department of Pulmonary and Critical Care Medicine, King George's Medical University, Lucknow, Uttar Pradesh, India.
Background And Objective: Obstructive sleep apnea (OSA) is a common condition, featured by repetitive upper airway collapse during sleep manifested with poor quality of life and co-morbidities. Although continuous positive airway pressure (CPAP) is the recommended therapy, lack of patient compliance and persistent symptoms often preclude its success. The present study evaluates the effect of acetazolamide in combination with CPAP, and compares this treatment strategy to single therapy using CPAP in moderate to severe OSA.
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