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The interplay of senescence and MMPs in myocardial infarction: implications for cardiac aging and therapeutics.
Biogerontology
January 2025
Centre for Global Health Research, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.
Aging is associated with a marked increase in cardiovascular diseases, such as myocardial infarction (MI). Cellular senescence is also a crucial factor in the development of age-related MI. Matrix metalloproteinases (MMPs) interaction with cellular senescence is a critical determinant of MI development and outcomes, most notably in the aged heart.
View Article and Find Full Text PDFFormulation, Optimization, and Evaluation of Lornoxicam-Loaded Novasomes for Targeted Ulcerative Colitis Therapy: In Vitro and In Vivo Investigations.
J Drug Target
January 2025
Department of Industrial Pharmacy, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, Giza, Egypt.
The purpose of this work was to create and assess Lornoxicam (LOR) loaded Novasomes (Novas) for the efficient treatment of ulcerative colitis. The study was performed using a 2 factorial design to investigate the impact of several formulation variables. Three separate parameters were investigated: Surface Active agent (SAA) type (), LOR concentration (), and SAA: Oleic acid ratio ().
View Article and Find Full Text PDFLignin-Based Nanoparticles Stabilized Pickering Emulsion for Enhanced Catalytic Hydrogenation.
Langmuir
January 2025
Department of Materials-Oriented Chemical Engineering, School of Chemical Engineering, Fuzhou University, Fuzhou 350116, P. R. China.
The development of green and easily regulated amphiphilic particles is crucial for advancing Pickering emulsion catalysis. In this study, lignin particles modified via sulfobutylation were employed as solid emulsifiers to support Pd nanoparticles (NPs), thereby enhancing the catalytic efficiency of biphasic reactions. Sulfobutylation of lignin effectively adjusted the hydrophilic-hydrophobic balance, resulting in controlled emulsion types and droplet sizes.
View Article and Find Full Text PDFDifferential homing of monocytes and neutrophils in the epithelial layer of HSV-1 infected cornea regulates viral dissemination and wound healing.
Ocul Surf
January 2025
Department of Ophthalmology, Visual and Anatomical Sciences, Wayne State University School of Medicine, Detroit, MI, USA. Electronic address:
Purpose: To ascertain the homing of monocytes and neutrophils in the epithelium versus stroma of HSV-1 infected corneas at different stages of infection and functional significance of their anatomical location in virus-infected corneas.
Methods: The corneas of C57BL/6J mice were infected with HSV-1 McKrae. Mice were euthanized on different days post-infection.
Mechanistic origins of temperature scaling in the early embryonic cell cycle.
bioRxiv
December 2024
Laboratory of Dynamics in Biological Systems, Department of Cellular and Molecular Medicine, KU Leuven, Herestraat, 49, Leuven, Belgium.
Temperature profoundly impacts organismal physiology and ecological dynamics, particularly affecting ectothermic species and making them especially vulnerable to climate changes. Although complex physiological processes usually involve dozens of enzymes, empirically it is found that the rates of these processes often obey the Arrhenius equation, which was originally derived for single-enzyme-catalyzed reactions. Here we have examined the temperature scaling of the early embryonic cell cycle, with the goal of understanding why the Arrhenius equation approximately holds and why it breaks down at temperature extremes.
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