AI Article Synopsis
- The study focused on analyzing how different types of antibodies in human blood respond to β-glucan, a key component of fungal cell walls.
- Researchers used a specific test to measure the levels and reactions of anti-BG antibodies, identifying IgG as the most prevalent antibody type.
- Findings revealed that the reactivity of these antibodies varies with the source of β-glucan, and they suggest that anti-BG antibodies have distinct roles in fighting fungal infections based on their class.
Article Abstract
The aim of this work was to characterize an antibody response to β-glucan (BG), a major component of the fungal cell wall, at each isotype in human sera. The titer and reactivity of the anti-human BG antibody were examined using enzyme-linked immunosorbant assay plates coated with Candida soluble cell wall β-glucan as a standard antigen. The antibody was detected using anti-human immunoglobulin (Ig) G, IgM, and IgA. Its major class was IgG in all subjects. The antibody titer varied significantly. The anti-BG antibody showed greater reactivity to β-glucans derived from pathogenic fungi than monoglycosyl-branched β-glucans derived from mycelia culture medium. In addition, it was suggested that the anti-BG IgM antibody was bound relatively strongly to the β1,3-glucan backbone and the anti-BG IgG antibody to β1,6-glucan. The anti-BG antibody plays a variety of roles, according to class, in the host's response to fungi. We propose a new index of human response to β-glucan that effects the understanding of the response to β-glucan in humans.
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| http://dx.doi.org/10.1615/intjmedmushr.v15.i2.10 | DOI Listing |
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