AI Article Synopsis
- Arginase serum levels are elevated in patients with human African trypanosomiasis but normalize after treatment.
- Arginase breaks down l-arginine into l-ornithine, which is crucial for the growth of the parasite causing the disease.
- Decreased l-arginine can weaken immune responses, suggesting that arginase levels could serve as a marker for how effective the treatment is.
Article Abstract
Arginase serum levels were increased in human African trypanosomiasis patients and returned to control values after treatment. Arginase hydrolyzes l-arginine to l-ornithine, which is essential for parasite growth. Moreover, l-arginine depletion impairs immune functions. Arginase may be considered as a biomarker for treatment efficacy.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697696 | PMC |
| http://dx.doi.org/10.1128/JCM.03371-12 | DOI Listing |
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