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In patients with transplant-eligible newly diagnosed multiple myeloma, induction therapy with a quadruplet regimen prior to autologous transplant is the standard of care. The phase III IFM2020-02-MIDAS study (NCT04934475) assessed a minimal residual disease (MRD)-driven consolidation and maintenance strategy following induction with isatuximab, carfilzomib, lenalidomide, and dexamethasone (IsaKRD). Here, we report safety and efficacy outcomes of six 28-day cycles of IsaKRD.
View Article and Find Full Text PDFBasal implants as a treatment alternative for severely resorbed ridges.
Minerva Dent Oral Sci
January 2025
RAK College of Dental Sciences, Department of Prosthodontics, RAK Medical and Health Sciences University, Ras Al-Khaimah, United Arab Emirates.
Introduction: The aim of this study was to evaluate the long-term treatment outcomes of basal implants in patients with severely resorbed ridges, including the survival and success rates, patient complaints, satisfaction, and Quality of Life.
Evidence Acquisition: An extensive electronic search was conducted on the search engines: PubMed, Web of Science, and Google Scholar using Boolean Operators (AND, OR, NOT) and the key words (basal implants, Corticobasal implants, Strategic Implants, severely resorbed ridge, severely atrophic ridge, treatment outcome, patient satisfaction) within the last 10 years.
Evidence Synthesis: A total of 21 articles were found, encompassing 9732 basal implants placed in 1219 patients.
[The impact of innate immune response on the efficacy of oncolytic viruses].
Vopr Virusol
December 2024
Oncolytic viruses represent a promising class of immunotherapeutic agents for the treatment of malignant tumors. The proposed mechanism of action of various oncolytic viruses has initially been explained by the ability of such viruses to selectively lyse tumor cells without damaging healthy ones. Recently, there have emerged more studies determining the effect of the antiviral immunostimulating mechanisms on the effectiveness of treatment in cancer patients.
View Article and Find Full Text PDFEfficacy of Ceftazidime-avibactam in treating Gram-negative infections: a systematic review and meta-analysis.
Eur J Clin Microbiol Infect Dis
January 2025
University of Sassari, Sassari, Italy.
Introduction: Ceftazidime-avibactam (CAZ-AVI) has emerged as a promising treatment option for Gram-negative infections, particularly those caused by CAZ-Non-Susceptible (NS) pathogens. This systematic review and meta-analysis aim to assess the efficacy and safety of CAZ-AVI in these challenging infections.
Methods: We systematically queried EMBASE, Cochrane CENTRAL, and PubMed/Medline for studies published until September 15, 2024.
Vascular Access and Closure Management for Electrophysiological Interventions: Small Interventions Big Impact.
Curr Cardiol Rep
January 2025
Heart Division, Royal Brompton Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Purpose Of The Review: This review examines the role of vascular access and closure management in cardiac electrophysiology (EP) procedures, emphasising their impact on patient outcomes and safety. It synthesises current evidence and highlights advancements, challenges, and opportunities in this critical area of EP practice.
Recent Findings: Ultrasound-guided vascular access has significantly reduced complications and improved success rates compared to traditional methods.
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