Objective: To assess the influence of infertility and fertility drugs on risk of ovarian tumors.
Design: Case-control study (Mayo Clinic Ovarian Cancer Study).
Setting: Ongoing academic study of ovarian cancer.
Patient(s): A total of 1,900 women (1,028 with ovarian tumors and 872 controls, frequency matched on age and region of residence) who had provided complete information in a self-report questionnaire about history of infertility and fertility drug use.
Intervention(s): None.
Main Outcome Measure(s): Effect of infertility history, use of fertility drugs and oral contraception, and gravidity on the risk of ovarian tumor development, after controlling for potential confounders.
Result(s): Among women who had a history of infertility, use of fertility drugs was reported by 44 (24%) of 182 controls and 38 (17%) of 226 cases. Infertile women who used fertility drugs were not at increased risk of developing ovarian tumors compared with infertile women who did not use fertility drugs; the adjusted odds ratio was 0.64 (95% CI, 0.37, 1.11). The findings were similar when stratified by gravidity and when analyzed separately for borderline versus invasive tumors.
Conclusion(s): We found no statistically significant association between fertility drug use and risk of ovarian tumors. Further larger, prospective studies are needed to confirm this observation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672269 | PMC |
| http://dx.doi.org/10.1016/j.fertnstert.2013.02.010 | DOI Listing |
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