Impact of angiographic & procedural factors on the treatment of ostial LAD or LC(x) disease.

Aims & Objectives: This study was designed to evaluate the impact of angiographic & procedural factors on MACE after DES deployment in ostial lesions of LAD & LC(x). PATIENTS, MATERIALS & METHODS: 65 patients with ostial disease of LAD or LC(x) underwent PCI using DES. In 56 patients the stent was placed perfectly at the ostium & in 9 patients the LMCA was covered as per protocol. Angiographically 48 patients had a bifurcation angle > 70 degrees whereas in 17 patients the angle was < 70 degrees. RESULT & ANALYSIS: Multivariate Regression Analysis was done. Mean age was 59 years & 77% were male patients. 69% were hypertensives & 52% diabetics. LAD was treated in 88%. 74% had bifurcation angle > 70 degrees. 26% presented with an angle < 70 degrees LMCA was covered during stent implantation in 12% of cases. Average follow up was 1.5 +/- 0.8 years. Overall MACE was 12%. Bifurcation angle > 70 degrees & use of Cypher stent remained significant in reduction of MACE (P < 0.05). Using Univariate analysis of 2 sample sets like cases with angle of separation > 70 degrees (n = 48) & with angle less than < 70 degrees (n = 17), it was found that covering LMCA was beneficial in cases with angle of separation < 70 degres (p-value and correlation coefficient nearer to statistical significance).

Conclusion: Angiographic factors like bifurcation angle is important to formulate the strategy of stenting procedure in the ostial disease of LAD or LC(x) even with DES.