Patients with occult cancer of systemic or intracranial origin may clinically present with stroke as an initial manifestation due to tumor-associated hemorrhage and/or infarction. Such cases are usually clearly temporally related. We present a case with separate instances of hemorrhagic infarction and subsequent glioblastoma that were temporally separated by several years. This case may be an illustration of recent findings in mechanisms of brain repair and tumor biology.
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