AI Article Synopsis
- The study assessed the clinical traits, sperm retrieval, and birth rates in infertile patients with Y chromosome microdeletions, analyzing data from 289 patients classified as NOA or OATS.
- Among the 110 patients with Y chromosome microdeletions, a majority had NOA, with different types of microdeletions affecting sperm retrieval outcomes, notably AZFb-c losing all sperm while AZFc showed some success.
- Overall, the findings suggest no significant difference in sperm retrieval rates between patients with and without microdeletions, but shorter microdeletions like AZFc correlate with better chances of successful sperm retrieval and higher birth rates.
Article Abstract
Purpose: We evaluated clinical characteristics, sperm retrieval rates, and birth rates in a relatively large number of infertile patients with Y chromosome microdeletions.
Materials And Methods: We retrospectively reviewed clinical data from 213 patients with nonobstructive azoospermia (NOA) and 76 patients with oligoasthenoteratozoospermia (OATS) who were tested for Y chromosome microdeletion from March 2004 to June 2011.
Results: Of the 289 patients, 110 patients presented with Y chromosome microdeletion and 179 patients presented with no microdeletion. Among the patients with Y chromosome microdeletions, 83/110 (75.4%) were NOA patients and 27/110 (24.5%) were OATS patients. After subdividing the patients with Y chromosome microdeletion, 29 had azoospermia factor (AZF)b-c microdeletion and 81 had AZFc microdeletion. The sperm retrieval rate was similar between patients with Y chromosome microdeletion and those with no microdeletion (26.6% vs. 25.6%, p=0.298) after multiple testicular sperm extraction (TESE). Excluding 53 patients who did not undergo TESE, 30 patients were analyzed. All of the 9 men with AZFb-c microdeletion had a complete absence of sperm despite multiple TESE. However, multiple TESE was successful for 9 of 21 patients with only AZFc microdeletion (p=0.041). Twenty patients with Y chromosome microdeletion gave birth.
Conclusions: In NOA and OATS patients, no significant difference in the sperm retrieval rate was shown between patients with Y chromosome microdeletion and those with no microdeletion. Patients with short Y chromosome microdeletion such as AZFc microdeletion have better prognoses for sperm retrieval and an increased chance of conception than do patients with larger microdeletions such as AZFb-c microdeletion.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580300 | PMC |
| http://dx.doi.org/10.4111/kju.2013.54.2.111 | DOI Listing |
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