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GLP-1RA based therapies in the young and old.
Curr Opin Endocrinol Diabetes Obes
February 2025
Austin Health, Continuing Care.
Purpose Of Review: Obesity is recognized as a "gateway" chronic, progressive disease of dysfunctional adipocytes. Glucagon-like peptide-1 receptor agonist-based therapies (GLP1BTs), including glucagon-like peptide-1 receptor agonists (GLP-1 RAs) with/without glucose-dependent insulinotropic polypeptide (GIP), have demonstrated clinically significant weight loss and health gains in adults, hence interest in using them in younger and older people. Therefore, reviewing the role of GLP1BTs in these populations is pertinent and timely.
View Article and Find Full Text PDFRegistration and management of children with overweight by general practitioners in The Netherlands.
Eur J Gen Pract
December 2024
Department of General Practice, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Background: General practitioners (GPs) form the gateway to healthcare in numerous European countries. Their role in addressing and managing overweight/obesity in children is crucial. In Dutch guidelines, GPs are encouraged to proactively address weight-related issues during patient consultations, regardless of the initial reason of the visit.
View Article and Find Full Text PDFArticle Synopsis
- Adolphe Quetelet's 1835 work provided a mathematical analysis showing that body weight is approximately proportional to height in adults, a concept that later evolved into what we now call body mass index (BMI).
- BMI has become a global standard for assessing body fatness at both individual and population levels, evolving through extensive scientific discourse.
- The rise of effective weight loss treatments has sparked renewed examination of BMI's origins and its appropriateness for diagnosing obesity, emphasizing the importance of understanding its historical and mathematical basis for students and practitioners in health fields.
Stress-induced overeating behaviors explained from a (transitory) relief-learning perspective.
Physiol Behav
December 2024
Laboratory of Biological Psychology, Faculty of Psychology and Educational Sciences, KU Leuven, Belgium; Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Cognitive Neuroscience Department. Electronic address:
People use various behaviors to cope with stressful events. These behaviors are mostly adaptive, as they allow a successful release of stress without impacting other aspects of life: How nice is it to have a break with a few spoons of that favorite ice cream during a hectic working day? However, when excessive consumption of high-sugar/salt ultra-processed food becomes the gateway to find relief from stress, eating loses this adaptive function and may escalate to binge eating, lead to obesity, and other medical conditions linked to overweight. Several etiological models attempt to explain stress-induced eating and excessive overeating behaviors characterizing these clinical conditions.
View Article and Find Full Text PDFThe role of tissue oxygenation in obesity-related cardiometabolic complications.
Rev Endocr Metab Disord
September 2024
Department of Human Biology, Institute of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University Medical Centre+, PO Box 616, Maastricht, 6200 MD, The Netherlands.
Obesity is a complex, multifactorial, chronic disease that acts as a gateway to a range of other diseases. Evidence from recent studies suggests that changes in oxygen availability in the microenvironment of metabolic organs may exert an important role in the development of obesity-related cardiometabolic complications. In this review, we will first discuss results from observational and controlled laboratory studies that examined the relationship between reduced oxygen availability and obesity-related metabolic derangements.
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