AI Article Synopsis
- Cystatin C (Cyst C) is highlighted as a more sensitive marker for detecting early renal injury compared to traditional markers like serum creatinine (sCr) and estimated glomerular filtration rate (eGFR) following endovascular aortic aneurysm repair (EVAR).
- The study involved 29 patients who were monitored for changes in Cyst C, sCr, and eGFR before and after the EVAR procedure, with significant increases in Cyst C observed 24 hours post-surgery and sustained for up to 12 months.
- In contrast, sCr and eGFR only showed significant changes immediately after the procedure, suggesting they may not effectively capture long-term renal damage associated
Article Abstract
Background: Cystatin C (Cyst C) is more sensitive marker for early renal injury. However, serum creatinine (sCr) and estimated glomerular filtration rate (eGFR) are still used as the standard renal markers after endovascular aortic aneurysm repair (EVAR). The goal of this study was to compare the efficacy of Cyst C, sCr, and eGFR as markers of renal function after EVAR.
Patients And Methods: This study examined 29 patients (27 men) with a mean age of 76.9 years (range, 55-89 years) undergoing standard (n = 19) and fenestrated (n = 10) EVAR for abdominal aortic aneurysm (AAA) of mean diameter 6.9 cm (range, 5.5-10 cm). Cyst C and sCr were measured and eGFR calculated before and 1 day and 1, 6, and 12 months after EVAR.
Results: At 24 hours after procedure, a significant increase in Cyst C (P < 0.005) and sCr (P = 0.028) and significant decrease in eGFR (P = 0.04) were seen. Cyst C continued to increase and was significantly higher at 1 (P < 0.002), 6 (P < 0.005), and 12 (P < 0.005) months compared with baseline. By contrast, sCr and eGFR did not show any significant change at 1, 6, and 12 months from the baseline level. Cyst C increased significantly postoperatively regardless of the baseline renal function. None of the patients required renal replacement therapy.
Conclusions: EVAR is associated with a significant increase in Cyst C starting 24 hours after the procedure and is maintained for 12 months. sCr and eGFR only show significant change at 24 hours and therefore may underestimate long-term renal damage after EVAR.
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| http://dx.doi.org/10.1016/j.avsg.2012.06.016 | DOI Listing |
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