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Anticoagulant Overdose With Paradoxical Thrombotic Risk.
Cureus
December 2024
Intensive Care Medicine, St George Hospital, Sydney, AUS.
We report a case of an unusual polypharmacy overdose including warfarin in a patient with a metallic heart valve, complicated by the history that he had ceased taking anticoagulation in the preceding few months, that placed him in an initial prothrombotic phase during his presentation. Our case highlights the importance of elucidating all relevant clinical details in a polypharmacy overdose, as clearly and rapidly as feasible, to enable appropriate management.
View Article and Find Full Text PDFInstruments for assessing healthcare professionals' knowledge, attitudes and practices regarding deprescribing: a scoping review protocol.
BMJ Open
January 2025
Department of Pharmaceutical Sciences, University of Sorocaba, Sorocaba, Brazil
Objective: To map instruments for assessing healthcare professionals' knowledge, attitudes and practices regarding deprescribing.
Introduction: Deprescribing is essential for improving patient outcomes by managing polypharmacy, reducing fall risks and decreasing medication costs. However, there is a limited exploration of healthcare professionals' perspectives about deprescribing.
An Educational Intervention to Promote Central Nervous System-Active Deprescribing in Dementia: A Pilot Study.
Drugs Aging
January 2025
Center for Clinical Management Research, VA Ann Arbor Healthcare System, NCRC 016-308E, 2800 Plymouth Rd, Ann Arbor, MI, 48109, USA.
Background: Central nervous system (CNS)-active polypharmacy (defined as concurrent exposure to three or more antidepressant, antipsychotic, antiseizure, benzodiazepine, opioid, or nonbenzodiazepine benzodiazepine receptor agonists) is associated with significant potential harms in persons living with dementia (PLWD).We conducted a pilot trial to assess a patient nudge intervention's implementation feasibility and preliminary effectiveness to prompt deprescribing conversations between PLWD experiencing CNS-active polypharmacy and their primary care clinicians ("clinicians").
Methods: We used the electronic health record to identify PLWD prescribed CNS-active polypharmacy in primary care clinics from two health systems.
Prevalence and Associations of Xerostomia in Older Adults in Southern Brazil.
Gerodontology
January 2025
Post-Graduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.
Objectives: This study investigated the prevalence and associations of xerostomia in older adults in southern Brazil.
Methods: A cross-sectional study was carried out in Pelotas, Brazil, during 2014. A representative sample of the city's older adult population (60+) was selected.
[Issues in the diagnosis of pneumonia in elderly patients].
Zhonghua Jie He He Hu Xi Za Zhi
January 2025
Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing100191, China.
In elderly patients, the onset of pneumonia is often subtle and typical respiratory symptoms are less common. Instead, non-specific presentations such as altered mental status and loss of appetite should be closely monitored. The sensitivity of chest X-rays and routine laboratory tests is often low, so a comprehensive assessment including risk factors is required.
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