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Quantity of delta-9-tetrahydrocannabinol consumption and cannabis use disorder among daily cannabis consumers.
Addiction
November 2024
Center for Technology and Behavioral Health, Dartmouth Geisel School of Medicine, Lebanon, NH, USA.
Article Synopsis
- - The study investigates the risks of cannabis use disorder (CUD) among daily consumers in the U.S., focusing on the relationship between the amount of delta-9-tetrahydrocannabinol (THC) consumed daily and CUD severity.
- - A large sample of 4,134 adult participants provided data through an online survey assessing cannabis consumption patterns and CUD criteria, leading to an average daily consumption of about 130 mgTHC.
- - Results indicated that higher daily THC intake was linked to more severe CUD, with 65% of participants meeting CUD criteria—39% with mild, 18% with moderate, and 8% with severe cases.
Multiple roles for hypoxia inducible factor 1-alpha in airway epithelial cells during mucormycosis.
Nat Commun
June 2024
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Article Synopsis
- In pulmonary mucormycosis, inhaled spores invade airway cells, with HIF1α playing a crucial role in this infection process.
- HIF1α signaling activates during infection, leading to increased expression of pro-inflammatory genes, but inhibiting it reduces fungal invasion and boosts survival in mouse models.
- The study highlights HIF1α's dual function: it aids the fungus in invading cells while also helping the host defend against the infection.
From heterosis to outbreeding depression: genotype-by-environment interaction shifts hybrid fitness in opposite directions.
Genetics
August 2024
Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA.
In F1 hybrids, phenotypic values are expected to be near the parental means under additive effects or close to one parent under dominance. However, F1 traits can fall outside the parental range, and outbreeding depression occurs when inferior fitness is observed in hybrids. Another possible outcome is heterosis, a phenomenon that interspecific hybrids or intraspecific crossbred F1s exhibit improved fitness compared to both parental species or strains.
View Article and Find Full Text PDFChronic pain, cannabis legalisation, and cannabis use disorder among patients in the US Veterans Health Administration system, 2005 to 2019: a repeated, cross-sectional study.
Lancet Psychiatry
November 2023
Health Services Research & Development (HSR&D) Seattle Center of Innovation for Veteran-Centered and Value-Driven Care, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA; Center of Excellence in Substance Addiction Treatment and Education, VA Puget Sound Health Care System, Seattle, WA, USA; University of Washington School of Medicine, Seattle, WA, USA.
Article Synopsis
- Cannabis use disorder is increasingly prevalent among adults with chronic pain, prompting an assessment of the impact of medical and recreational cannabis laws on this trend among patients in the US Veterans Health Administration (VHA).
- The study analyzed data from VHA patients between 2005-2019, utilizing a robust statistical approach to evaluate how the introduction of these cannabis laws correlated with diagnosed cannabis use disorder in relation to chronic pain conditions.
- Findings revealed demographic shifts over the years, including increased female representation and changes in racial demographics among patients, highlighting that cannabis use disorder is becoming a significant concern within this population.
Use of Lysergic Acid Diethylamide by Major Depression Status.
JAMA Psychiatry
January 2024
Department of Translational Epidemiology, New York State Psychiatric Institute, New York.
Importance: Renewed interest in the clinical potential of hallucinogens may lead people with depression to a generally more positive view of the use of lysergic acid diethylamide (LSD). Therefore, past-year LSD use among people with depression may be increasing in prevalence.
Objective: To assess time trends in the prevalence of past-year nonmedical LSD use by past-year major depression status and the variation in this association by sociodemographic characteristics.
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