Compounds with different modes of action may affect life cycles of biota differently. The aim of the present study was therefore to investigate the impact of four chemicals with different modes of action, including the essential metal copper, the nonessential metal cadmium, the organometal tributyltin, and the polycyclic aromatic compound phenanthrene, on chronic lethal and sublethal life-cycle effect parameters of the nonbiting midge Chironomus riparius, applying a 28-day sediment toxicity test. Tributyltin and cadmium delayed emergence significantly over a wide range of sublethal concentrations, while this range was narrow for copper and almost absent for phenanthrene. The chronic LC50/LOECEmT50 ratio, expressing these differences, amounted to 1.5, 3.5, 12.0, and 18.2 for respectively phenanthrene, copper, cadmium, and tributyltin. Thus the more specific the compounds mode of action, the higher the chronic LC50/LOECEmT50 ratio, as previously observed for acute-to-chronic ratios (ACRs). Comparison of our results with literature derived LC50/LOEC ratios showed a comparable trend and a lower variability compared to ACRs. We therefore conclude that the presently proposed chronic ratio is indicative for the specificity of a chemicals mode of action and that it is less variable than the ACR.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/es102904y | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Senotherapy: Implications for Transplantation.
Transplantation
January 2025
Interdisciplinary Transplantation, Children's Hospital, Hannover Medical School, Hannover, Germany.
Cellular senescence has been identified as a potential driver of age-associated loss of organ function and as a mediator of age-related disease. Novel strategies in targeting senescent cells have shown promise in several organ systems to counteract functional decline, chronic inflammation, and age-dependent loss of repair capacity. Transgenic models have provided proof of principle that senolysis, the elimination of senescent cells, is an attractive strategy to overcome many age-related pathologies.
View Article and Find Full Text PDFPredicting and managing liver fibrosis in biliary atresia.
Semin Pediatr Surg
January 2025
Section of Pediatric Surgery, Pediatric Liver and Gut Research Group, New Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Pediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Department of Women's and Children's Health, Karolinska Institute, Stockholm, Sweden. Electronic address:
Regardless of the underlying etiology and success of PE, progressive liver fibrosis and eventually cirrhosis represent the dominant pathology and the end-stage of BA. Ascending bile duct injury-induced cholestasis, inflammation and ductular reaction provide profibrogenic cytokine environment leading to myofibroblast activation and rapid progression of fibrosis especially after unsuccessful portoenterostomy. Although liver fibrosis and development of cirrhosis play a crucial role in determining BA outcomes, the exact prognostic significance and dynamics of mild to moderate liver fibrosis remain unclear.
View Article and Find Full Text PDFEvaluation of interspecies correlation estimation models to increase taxonomic diversity while reducing reliance on animal testing for chemicals evaluated under the Toxic Substances Control Act.
Integr Environ Assess Manag
January 2025
Office of Chemical Safety Office Pollution Prevention, Office of Pollution Prevention and Toxics, US Environmental Protection Agency, Washington, DC, United States.
The U.S. Environmental Protection Agency is committed to the implementation of new approach methodologies (NAMs) to enhance the scientific basis for chemical hazard assessments.
View Article and Find Full Text PDFA novel ADP-directed chaperone function facilitates the ATP-driven motor activity of SARS-CoV helicase.
Nucleic Acids Res
January 2025
Single-Molecule and Cell Mechanobiology Laboratory, Daejeon, 34141, South Korea.
Helicase is a nucleic acid motor that catalyses the unwinding of double-stranded (ds) RNA and DNA via ATP hydrolysis. Helicases can act either as a nucleic acid motor that unwinds its ds substrates or as a chaperone that alters the stability of its substrates, but the two activities have not yet been reported to act simultaneously. Here, we used single-molecule techniques to unravel the synergistic coordination of helicase and chaperone activities, and found that the severe acute respiratory syndrome coronavirus helicase (nsp13) is capable of two modes of action: (i) binding of nsp13 in tandem with the fork junction of the substrate mechanically unwinds the substrate by an ATP-driven synchronous power stroke; and (ii) free nsp13, which is not bound to the substrate but complexed with ADP in solution, destabilizes the substrate through collisions between transient binding and unbinding events with unprecedented melting capability.
View Article and Find Full Text PDFHarnessing the power of cinnamon oil: A review of its potential as natural biopesticide and its implications for food security.
Heliyon
January 2025
Research Center for Pharmaceutical Ingredients and Traditional Medicine, National Research and Innovation Agency (BRIN), Complex Cibinong Science Center-BRIN, Cibinong, 16911, Jawa Barat, Indonesia.
The escalating concerns about the environmental and health impacts of synthetic pesticides have intensified the search for sustainable and effective alternatives. Cinnamon oil, derived from the bark of Cinnamomum species, has emerged as a promising candidate in this arena due to its potent biopesticidal properties. This review explores the multifaceted role of cinnamon oil in agricultural pest management, emphasizing its potential to contribute significantly to food security.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!