AI Article Synopsis
- Carboxymethyl sago pulp (CMSP) was created using sago waste and formed into beads averaging 3.1-4.8 mm through aluminum chloride gelation and irradiation cross-linking.
- The CMSP beads were used to encapsulate a model drug, 5-aminosalicylic acid (5-ASA), and studies indicated that the drug remained intact and amorphous within the beads.
- Drug release was pH-dependent, with about 90% of 5-ASA released at pH 7.4 over 9 hours, while irradiated beads showed better resistance to release in acidic conditions compared to non-irradiated beads.
Article Abstract
The carboxymethyl sago pulp (CMSP) with a degree of substitution of 0.4% was synthesized from sago waste. The CMSP beads with an average diameter of 3.1-4.8 mm were formed by aluminium chloride gelation as well as further cross-linked by irradiation. To evaluate colon targeted release, a model drug, 5-aminosalicylic acid (5-ASA) was encapsulated in CMSP beads. Fourier-transform infrared spectroscopy and X-ray diffraction studies indicated intact and amorphous nature of entrapped drug. A pH dependent drug release was observed, and about 90% of the drug was released only at pH 7.4 over 9 h. Irradiated beads were resisted the drug release in an acidic environment at a higher extent than non-irradiated beads. The drug release from 6% (w/w) of 5-ASA loaded bead followed zero order, whereas, 15 and 22% loaded beads followed first order. The release exponent n value suggests non-fickian transport of 5-ASA from the beads.
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| http://dx.doi.org/10.1016/j.carbpol.2013.01.004 | DOI Listing |
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