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The bromodomain and extra-terminal (BET) family of proteins reads epigenetic histone acetylation marks on the genome and regulates the transcriptional machinery. In their study, Carole LaBonne and colleagues reveal the role of BET protein activity in the maintenance of pluripotency and establishment of the neural crest in Xenopus laevis. To know more about their work, we spoke to the first author Paul Huber and the corresponding author Carole LaBonne, Developmental and Stem Cell Biologist at Northwestern University.
View Article and Find Full Text PDFKeratoconus and the Impact of Treatment on Patients' Quality of Life: A Qualitative Study.
Ophthalmol Ther
August 2023
ICON Plc, Lyon, France.
Introduction: Keratoconus has a significant impact on patients' quality of life (QoL), from diagnosis to the advanced stages of the disease. The aim of this research was to identify domains of QoL affected by this disease and its treatment.
Methods: Phone interviews were conducted using a semi-structured interview guide, with patients with keratoconus stratified according to their current treatment.
[Establishing at a shared and common educational assessment at Curie Institute].
Bull Cancer
November 2021
Hôpital Institut Curie, département de soins de supports, 26, rue d'Ulm, 75005 Paris, France.
The Institut Curie initiated a therapeutic patient education activity in 2011 by creating several programs. Coordinated and animated by different multidisciplinary teams, these functioned autonomously, with a different initial educational assessment for each one. This organization broke up the patient's educational pathway, and the educational offer, which sometimes proved to be redundant, most often corresponding to the needs shared by all cancer patients.
View Article and Find Full Text PDFEvaluation of an advance care planning web-based resource: applicability for cancer treatment patients.
Support Care Cancer
March 2018
School of Medicine, San Francisco VA Medical Center, University of California San Francisco (UCSF), San Francisco, CA, USA.
Purpose: The purpose of this study was to explore the acceptability, applicability, and understandability of a promising advance care planning (ACP) web-based resource for use with oncology patients, and determine whether revisions to the website would be necessary before implementation into oncology care. The resource is called PREPARE ( www.prepareforyourcare.
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