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Similar Publications
Paederus Dermatitis: Two Outbreaks of an Entomologic Disease in Austere Expeditionary Care.
Mil Med
October 2024
Medicine, Wright Patterson Medical Center, Wright Patterson AFB, OH 45433, USA.
Paederus dermatitis, also known as dermatitis linearis, is an acute cutaneous condition caused by contact with the potent vesicant toxin paederin, produced by endosymbiotic Pseudomonas-like bacteria within Paederus spp. beetles. Paederin is a protein synthesis inhibitor that halts cell division, leading to vesiculation and necrotic breakdown of the epidermis.
View Article and Find Full Text PDFArticle Synopsis
- - Paederus contact dermatitis is a skin condition caused by beetles from the Paederus genus, which release a harmful toxin called paederin, commonly found in hot climates and during rainy seasons.
- - Symptoms include red patches with blisters on the skin, often accompanied by burning and itching, as demonstrated by a case of a 28-year-old male who developed lesions after vacationing in Ecuador.
- - Treatment involves washing the affected area, using topical steroids, and antihistamines; in the reported case, the patient improved significantly after 8 days, although some dark spots remained after the lesions healed.
The emerging role of FAM46C as a biomarker and therapeutic target in gastric adenocarcinoma.
J Gastrointest Oncol
August 2024
Department of Surgery, University of Toronto, Toronto, Canada.
Article Synopsis
- Gastric adenocarcinoma (GCa) has a high fatality rate in Europe and North America, largely due to late-stage diagnoses, despite advancements in treatment options.
- There is significant interest in FAM46C, a protein linked to tumor suppression, as its depletion is commonly observed in GCa patients and is associated with cancer recurrence and mortality.
- Research is exploring FAM46C as a potential biomarker and therapeutic target for GCa progression, with Norcantharidin emerging as a promising compound to restore FAM46C levels currently in phase one clinical trials.
Article Synopsis
- Insect gut microbiota significantly influence the diets and feeding habits of specialist blister beetle larvae, particularly those that consume locust eggs and artificial food.
- Analysis revealed that the gut microbiota structure remains similar among second to fourth instar larvae, but differs significantly in first instar larvae based on diet, suggesting that diet impacts microbial composition.
- The presence of bacteria that help with polysaccharide utilization is lower in first instar larvae, and an overload of polysaccharides in the artificial diet may hinder their growth, highlighting the need for optimized diets to support their nutritional needs.
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