From December 1986 through August 1988, 25 patients with intracranial arteriovenous malformations underwent radiosurgery with the dynamic stereotactic irradiation technique. The prescribed dose at isocenter ranged from 50 Gy to 55 Gy, given as a single fraction in 92% of the patients. Field sizes, defined at the 90% isodose surface, varied from 5 mm to 25 mm and were chosen in order to deliver 20 to 25 Gy at the periphery of the malformation. To date, 14 angiographic studies were repeated at 1 year posttreatment. In six patients (43%) a complete obliteration of the lesion was achieved. Late side effects were observed in three patients. Our initial analysis, at 1 year posttreatment, suggests that our results are comparable with those previously reported for other radiosurgical techniques. The linac-based dynamic stereotactic technique appears to be a valid alternative to radiosurgery with the Gamma unit or with heavy-charged particle beams.
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http://dx.doi.org/10.1002/1097-0142(19900701)66:1<15::aid-cncr2820660104>3.0.co;2-8 | DOI Listing |
Cancers (Basel)
January 2025
Department of Radiotherapy, Research Centre for Digital Medicine, VUB-UZ Brussel, 1090 Brussels, Belgium.
: Inadequate dosing and respiratory motion contribute to local recurrence for oligometastatic disease (OMD). While short-term LC rates are well-documented, data on long-term LC remain limited. This study investigated long-term LC after stereotactic body radiotherapy (SBRT), using respiratory motion management techniques.
View Article and Find Full Text PDFClin Oncol (R Coll Radiol)
January 2025
Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China; Department of Radiotherapy Physics & Technology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Aims: To assess the robustness of 4D-optimised IMPT and PAT plans against interplay effects in non-small cell lung cancer (NSCLC) patients with respiratory motion over 10 mm, and to provide insights into the use of proton-based stereotactic body radiotherapy (SBRT) for lung cancer with significant tumour movement.
Materials And Methods: Fourteen patients with early-stage NSCLC and tumour motion >10 mm were selected. Three hypofraction regimens were generated using 4D robust optimisation with the IMPT and PAT techniques.
Biomed Opt Express
January 2025
Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.
Abnormal corneal nerve function and associated disease is a significant public health concern. It is associated with prevalent ocular surface diseases, including dry eye disease. Corneal nerve dysfunction is also a common side effect of refractive surgeries, as well as a symptom of diseases that cause peripheral neuropathies.
View Article and Find Full Text PDFClin Transl Oncol
January 2025
Department of Radiation Oncology, HM Hospitales, Madrid, Spain.
Introduction: SRS for the treatment of limited brain metastases (BM) is widely accepted, but there are still limitations in the management of numerous BM. Frameless single-isocenter multitarget SRS is a novel technique that allows for rapid treatment delivery to multiple BM. We report our preliminary clinical, dosimetric, and patient´s shifts outcomes with this technique.
View Article and Find Full Text PDFTechnol Cancer Res Treat
January 2025
Department of Clinical Oncology, Medical University of Plovdiv, Plovdiv, Bulgaria.
The contemporary concept of carcinogenesis summarizes the role of hypoxia, neoangiogenesis, and hemostasis, including in the stage of progression and metastasis of the tumor process. Metastatic disease is a serious therapeutic challenge for any oncological condition. The purpose of this study was to evaluate the dynamics of specific indicators of neoangiogenesis and hypoxia as potential biomarkers for therapeutic efficacy or risk of disease progression in patients with brain metastases (BM) undergoing robotic stereotactic radiosurgery.
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